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Therapeutic and diagnostic implications of Hsp90 activation

Trends in molecular medicine, 2004-06, Vol.10 (6), p.283-290

2004

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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

Molecular cancer therapeutics, 2009-04, Vol.8 (4), p.921-929

2009

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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7786-7795

2012

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7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors

Journal of medicinal chemistry, 2006-08, Vol.49 (17), p.5352-5362

2006

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Nature (London), 1997-03, Vol.386 (6623), p.407-410

1997

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Nature, 2003-09, Vol.425 (6956), p.407-410

2003

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Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

Journal of clinical pharmacology, 2017-08, Vol.57 (8), p.988-996

2017

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Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Journal of medicinal chemistry, 1994-09, Vol.37 (18), p.2930-2941

1994

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Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study

Clinical pharmacology in drug development, 2018-03, Vol.7 (3), p.263-276

2018

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Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity

Journal of medicinal chemistry, 2007-06, Vol.50 (12), p.2767-2778

2007

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4087-4103

2003

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Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1593-1598

2004

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Vitamin D analogs: mechanism of action and therapeutic applications

Current medicinal chemistry, 2001-11, Vol.8 (13), p.1661

2001

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Cloning and expression of goldfish opsin sequences

Biochemistry (Easton), 1993-01, Vol.32 (1), p.208-214

1993

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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.817-828

2006

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Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3865-3873

2004

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Syntheses of High Specific Activity 2,3- and 3,4-[3H]2-9-cis-Retinoic Acid

Journal of organic chemistry, 1995-03, Vol.60 (5), p.1195-1200

1995

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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

Proceedings of the National Academy of Sciences - PNAS, 1995-06, Vol.92 (13), p.6157-6160

1995

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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

Journal of medicinal chemistry, 1995-08, Vol.38 (16), p.3146-3155

1995

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Stereoselective Synthesis of the C1−C13 Fragment of 2,3-Dihydrodorrigocin A

Journal of organic chemistry, 2005-09, Vol.70 (20), p.8212-8215

2005

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Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium

The Prostate, 2001-11, Vol.49 (3), p.224-233

2001

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Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.742-750

1999

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Engineering Orthogonal Ligand−Receptor Pairs from “Near Drugs”

Journal of the American Chemical Society, 2001-11, Vol.123 (46), p.11367-11371

2001

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9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation

Molecular and Cellular Biology, 1995-10, Vol.15 (10), p.5576-5585

1995

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Therapeutic and diagnostic implications of Hsp90 activation

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90

EC144 Is a Potent Inhibitor of the Heat Shock Protein 90

7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study

Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Vitamin D analogs: mechanism of action and therapeutic applications

Cloning and expression of goldfish opsin sequences

Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90

Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Syntheses of High Specific Activity 2,3- and 3,4-[3H]2-9-cis-Retinoic Acid

Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

Stereoselective Synthesis of the C1−C13 Fragment of 2,3-Dihydrodorrigocin A

Novel nonsecosteroidal vitamin D receptor modulator inhibits the growth of LNCaP xenograft tumors in athymic mice without increased serum calcium

Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells

Engineering Orthogonal Ligand−Receptor Pairs from “Near Drugs”

9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation

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