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Structural Basis for G Protein-Coupled Receptor Activation

Biochemistry (Easton), 2017-10, Vol.56 (42), p.5628-5634

2017

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Crystal structure of the human σ1 receptor

Nature (London), 2016-04, Vol.532 (7600), p.527-530

2016

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Protein design and variant prediction using autoregressive generative models

Nature communications, 2021-04, Vol.12 (1), p.2403-2403, Article 2403

2021

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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

Cell, 2019-01, Vol.176 (3), p.479-490.e12

2019

Volltextzugriff (PDF)

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Cell, 2016-11, Vol.167 (4), p.1041-1051.e11

2016

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Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Nature structural & molecular biology, 2018-03, Vol.25 (3), p.289

2018

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Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Cell, 2017-04, Vol.169 (2), p.338-349.e11

2017

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Nature (London), 2013-10, Vol.502 (7472), p.575-579

2013

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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6480), p.881-887

2020

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Nature (London), 2012-02, Vol.482 (7386), p.547-551

2012

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

Nature (London), 2013-12, Vol.504 (7478), p.101-106

2013

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Structural Basis of Smoothened Activation in Hedgehog Signaling

Cell, 2018-07, Vol.174 (2), p.312-324.e16

2018

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Structural basis of unidirectional export of lipopolysaccharide to the cell surface

Nature (London), 2019-03, Vol.567 (7749), p.550-553

2019

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Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant

Structure (London), 2016-10, Vol.24 (10), p.1719-1728

2016

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Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

Science (American Association for the Advancement of Science), 2020-02, Vol.367 (6480), p.888-892

2020

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

Science (American Association for the Advancement of Science), 2021-07, Vol.373 (6554), p.541-547

2021

Volltextzugriff (PDF)

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Nature (London), 2016-07, Vol.535 (7612), p.448-452

2016

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Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (47), p.E6506-E6514

2015

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T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

Immunity (Cambridge, Mass.), 2011-11, Vol.35 (5), p.681-693

2011

Volltextzugriff (PDF)

Structures of the σ2 receptor enable docking for bioactive ligand discovery

Nature (London), 2021-12, Vol.600 (7890), p.759-764

2021

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A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

PLoS genetics, 2018-10, Vol.14 (10), p.e1007726-e1007726

2018

Volltextzugriff (PDF)

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Nature (London), 2012-02, Vol.482 (7386), p.552-556

2012

Volltextzugriff (PDF)

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Nature (London), 2011-07, Vol.477 (7366), p.549-555

2011

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Allosteric activation of cell wall synthesis during bacterial growth

Nature communications, 2023-06, Vol.14 (1), p.3439-3439, Article 3439

2023

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Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

Nature (London), 2018-04, Vol.556 (7699), p.118-121

2018

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Structural Basis for G Protein-Coupled Receptor Activation

Crystal structure of the human σ1 receptor

Protein design and variant prediction using autoregressive generative models

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Structural Basis of Smoothened Activation in Hedgehog Signaling

Structural basis of unidirectional export of lipopolysaccharide to the cell surface

Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

Structures of the σ2 receptor enable docking for bioactive ligand discovery

A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Allosteric activation of cell wall synthesis during bacterial growth

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

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