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The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

Scientific reports, 2017-05, Vol.7 (1), p.1307-10, Article 1307

2017

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Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice

Nature neuroscience, 2016-04, Vol.19 (4), p.623-633

2016

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175

PloS one, 2012-12, Vol.7 (12), p.e49838-e49838

2012

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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.2366-2370

2013

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Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease

Movement disorders, 2014-09, Vol.29 (11), p.1397-1403

2014

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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

Human molecular genetics, 2020-11, Vol.29 (18), p.3044-3053

2020

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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease

PloS one, 2012-12, Vol.7 (12), p.e50717-e50717

2012

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MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

PloS one, 2018-01, Vol.13 (1), p.e0190550-e0190550

2018

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Focal Loss of the Glutamate Transporter EAAT2 in a Transgenic Rat Model of SOD1 Mutant-Mediated Amyotrophic Lateral Sclerosis (ALS)

Proceedings of the National Academy of Sciences - PNAS, 2002-02, Vol.99 (3), p.1604-1609

2002

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Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration

Neuron (Cambridge, Mass.), 2002-05, Vol.34 (5), p.715-727

2002

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Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

Neurobiology of disease, 2009-09, Vol.35 (3), p.319-336

2009

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Large genetic animal models of Huntington's Disease

Journal of Huntington's disease, 2013, Vol.2 (1), p.3-19

2013

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Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease

PloS one, 2012-02, Vol.7 (2), p.e31080

2012

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Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease

eNeuro, 2018-01, Vol.5 (1), p.ENEURO.0431-17.2017

2018

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Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

Scientific reports, 2017-10, Vol.7 (1), p.14275-14, Article 14275

2017

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A8 Large animal models in huntington’s disease: conceptual overview: what model to use for what purpose

Journal of neurology, neurosurgery and psychiatry, 2016-09, Vol.87 (Suppl 1), p.A3-A3

Howland, David

2016

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Impaired Spinal Cord Glutamate Transport Capacity and Reduced Sensitivity to Riluzole in a Transgenic Superoxide Dismutase Mutant Rat Model of Amyotrophic Lateral Sclerosis

The Journal of neuroscience, 2003-03, Vol.23 (5), p.1688-1696

2003

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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

Human molecular genetics, 2012-05, Vol.21 (9), p.1954-1967

2012

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Brain Region Specific Actions of Regulator of G Protein Signaling 4 Oppose Morphine Reward and Dependence but Promote Analgesia

Biological psychiatry (1969), 2010-04, Vol.67 (8), p.761-769

2010

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A transgenic minipig model of Huntington's Disease

Journal of Huntington's disease, 2013, Vol.2 (1), p.47-68

2013

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A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition

Neurobiology of aging, 2009-07, Vol.30 (7), p.1078-1090

2009

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Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs

Neuro-degenerative diseases, 2017-01, Vol.17 (4-5), p.213-226

2017

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Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline

PloS one, 2010-03, Vol.5 (3), p.e9793-e9793

2010

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Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars

Neuro-degenerative diseases, 2016-01, Vol.16 (3-4), p.245-259

2016

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The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

Focal Loss of the Glutamate Transporter EAAT2 in a Transgenic Rat Model of SOD1 Mutant-Mediated Amyotrophic Lateral Sclerosis (ALS)

Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

Large genetic animal models of Huntington's Disease

Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

A8 Large animal models in huntington’s disease: conceptual overview: what model to use for what purpose

Impaired Spinal Cord Glutamate Transport Capacity and Reduced Sensitivity to Riluzole in a Transgenic Superoxide Dismutase Mutant Rat Model of Amyotrophic Lateral Sclerosis

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

Brain Region Specific Actions of Regulator of G Protein Signaling 4 Oppose Morphine Reward and Dependence but Promote Analgesia

A transgenic minipig model of Huntington's Disease

A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition

Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs

Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars

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