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Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring BRAF

Oncogene, 2012-01, Vol.31 (4), p.446-457

2012

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Discovery of a novel Raf kinase inhibitor

Endocrine-related cancer, 2001-09, Vol.8 (3), p.219-225

2001

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

Nature biotechnology, 2005-02, Vol.23 (2), p.201-207

2005

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The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

Nephrology, dialysis, transplantation, 2011-11, Vol.26 (11), p.3458-3465

2011

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99 Proffered Paper: The Importance of Glycolysis for the Response and Resistance of BRAFV600E Human Melanoma Cells to Vemurafenib

European journal of cancer (1990), 2012-07, Vol.48, p.S24-S24

2012

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Phosphodiesterase-4 as a potential drug target

Expert opinion on therapeutic targets, 2005-12, Vol.9 (6), p.1283-1305

2005

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372 Preclinical Characterization of RG7256, a Potent and Selective BRAF Inhibitor with Differentiation From Vemurafenib

European journal of cancer (1990), 2012-11, Vol.48, p.114-114

2012

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A novel serine kinase activated by rac1/CDC42Hs‐dependent autophosphorylation is related to PAK65 and STE20

The EMBO journal, 1995-05, Vol.14 (9), p.1970-1978

1995

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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

The New England journal of medicine, 2015-07, Vol.373 (5), p.428-437

2015

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

Cancer research (Chicago, Ill.), 2004-10, Vol.64 (19), p.7099-7109

2004

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Germline KRAS mutations cause Noonan syndrome

Nature genetics, 2006-03, Vol.38 (3), p.331-336

2006

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Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice

Diabetes, obesity & metabolism, 2010-03, Vol.12 (3), p.234-245

2010

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529MO Activity, safety and circulating tumour DNA (ctDNA) dynamics of paradox breaker BRAF inhibitor PLX8394 in patients with advanced cancer

Annals of oncology, 2020-09, Vol.31, p.S465-S465

2020

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Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands

The Journal of biological chemistry, 2000-08, Vol.275 (33), p.25751-25759

2000

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Interim results from a phase 1/2 precision medicine study of PLX8394- a next generation BRAF inhibitor

European journal of cancer (1990), 2020-10, Vol.138, p.S2-S3

2020

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A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Molecular cell, 2004-07, Vol.15 (2), p.279-286

2004

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Characterization of full‐length neurofibromin: tubulin inhibits Ras GAP activity

The EMBO journal, 1993-05, Vol.12 (5), p.1923-1927

1993

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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

Structure (London), 2004-12, Vol.12 (12), p.2233-2247

2004

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p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

Science (American Association for the Advancement of Science), 1998-06, Vol.280 (5372), p.2109-2111

1998

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cA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Molecular cell, 2004-07, Vol.15 (2), p.279-286

2004

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GTPase activating proteins: critical regulators of intracellular signaling

BBA - Reviews on Cancer, 2002-03, Vol.1602 (1), p.23-45

2002

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The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT–dependent apoptosis in diffuse large B-cell lymphoma

Blood, 2005-01, Vol.105 (1), p.308-316

2005

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p115 RhoGEF, a GTPase Activating Protein for G$\alpha_{12}$ and G$\alpha_{13}

Science (American Association for the Advancement of Science), 1998-06, Vol.280 (5372), p.2109-2111

1998

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Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by G$\alpha_{13}

Science (American Association for the Advancement of Science), 1998-06, Vol.280 (5372), p.2112-2114

1998

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125 Targeting different conformations of BRAF kinase: efficacy of Omni-Raf inhibitors in NRAS and BRAF mutant tumors

European journal of cancer supplements, 2010, Vol.8 (7), p.46-46

2010

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Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring BRAF

Discovery of a novel Raf kinase inhibitor

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

99 Proffered Paper: The Importance of Glycolysis for the Response and Resistance of BRAFV600E Human Melanoma Cells to Vemurafenib

Phosphodiesterase-4 as a potential drug target

372 Preclinical Characterization of RG7256, a Potent and Selective BRAF Inhibitor with Differentiation From Vemurafenib

A novel serine kinase activated by rac1/CDC42Hs‐dependent autophosphorylation is related to PAK65 and STE20

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

Germline KRAS mutations cause Noonan syndrome

Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice

529MO Activity, safety and circulating tumour DNA (ctDNA) dynamics of paradox breaker BRAF inhibitor PLX8394 in patients with advanced cancer

Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands

Interim results from a phase 1/2 precision medicine study of PLX8394- a next generation BRAF inhibitor

A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Characterization of full‐length neurofibromin: tubulin inhibits Ras GAP activity

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

cA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

GTPase activating proteins: critical regulators of intracellular signaling

The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT–dependent apoptosis in diffuse large B-cell lymphoma

p115 RhoGEF, a GTPase Activating Protein for G$\alpha_{12}$ and G$\alpha_{13}

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by G$\alpha_{13}

125 Targeting different conformations of BRAF kinase: efficacy of Omni-Raf inhibitors in NRAS and BRAF mutant tumors

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