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PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia

European journal of medicinal chemistry, 2020-09, Vol.201, p.112411, Article 112411

2020

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Discovery of N -((3 S ,4 S )-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1 H -pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12163-12180

2021

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Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12203-12224

2023

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Entinostat in patients with relapsed or refractory abdominal neuroendocrine tumors

The oncologist (Dayton, Ohio), 2024-09, Vol.29 (9), p.817-e1213

2024

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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2651-2665

2019

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Rh(III)-Catalyzed Directed C−H Olefination Using an Oxidizing Directing Group: Mild, Efficient, and Versatile

Journal of the American Chemical Society, 2011-03, Vol.133 (8), p.2350-2353

2011

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Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

Nature (London), 2015-09, Vol.525 (7569), p.380-383

2015

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Effects of Selonsertib in Patients with Diabetic Kidney Disease

Journal of the American Society of Nephrology, 2019-10, Vol.30 (10), p.1980-1990

2019

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Molecular basis for ligand activation of the human KCNQ2 channel

Cell research, 2021-01, Vol.31 (1), p.52-61

2021

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Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W

Journal of clinical oncology, 2020-07, Vol.38 (21), p.2407-2417

2020

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An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.317-325

2013

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Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

European journal of medicinal chemistry, 2021-04, Vol.216, p.113316-113316, Article 113316

2021

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Chemical and Genetic Engineering of Selective Ion Channel—Ligand Interactions

Science (American Association for the Advancement of Science), 2011-09, Vol.333 (6047), p.1292-1296

2011

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Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis

Leukemia, 2013-06, Vol.27 (6), p.1322-1327

2013

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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

The Journal of clinical investigation, 2012-04, Vol.122 (4), p.1377-1392

2012

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NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas

Journal of clinical oncology, 2021-03, Vol.39 (7), p.797-806

2021

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The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model

Cell death & disease, 2018-05, Vol.9 (6), p.655-14, Article 655

2018

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Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib

Blood, 2020-07, Vol.136 (1), p.93-105

2020

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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

The Journal of pharmacology and experimental therapeutics, 2017-11, Vol.363 (2), p.240-252

2017

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Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

The lancet oncology, 2020-11, Vol.21 (11), p.1433-1442

2020

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A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700)

Forensic science international, 2016-09, Vol.266, p.68-72

2016

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Rhodium-Catalyzed Direct CH Amination of Benzamides with Aryl Azides: A Synthetic Route to Diarylamines

Angewandte Chemie (International ed.), 2012-09, Vol.51 (39), p.9904-9908

2012

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The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis

Drug testing and analysis, 2016-08, Vol.8 (8), p.875-879

2016

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PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia

Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial

Discovery of N -((3 S ,4 S )-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1 H -pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity

Discovery of Entrectinib: A New 3‑Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c‑ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders

Entinostat in patients with relapsed or refractory abdominal neuroendocrine tumors

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Rh(III)-Catalyzed Directed C−H Olefination Using an Oxidizing Directing Group: Mild, Efficient, and Versatile

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

Effects of Selonsertib in Patients with Diabetic Kidney Disease

Molecular basis for ligand activation of the human KCNQ2 channel

Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W

An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities

Chemical and Genetic Engineering of Selective Ion Channel—Ligand Interactions

Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model

Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700)

Rhodium-Catalyzed Direct CH Amination of Benzamides with Aryl Azides: A Synthetic Route to Diarylamines

The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis

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