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Oral, Direct Thrombin and Factor Xa Inhibitors: The Replacement for Warfarin, Leeches, and Pig Intestines?

Angewandte Chemie (International ed.), 2011-05, Vol.50 (20), p.4574-4590

2011

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Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

The Journal of biological chemistry, 2015-09, Vol.290 (36), p.21876-21889

2015

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Utility of homology models in the drug discovery process

Drug Discovery Today, 2004-08, Vol.9 (15), p.659-669

2004

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A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

The Journal of biological chemistry, 2010-09, Vol.285 (39), p.29932-29940

2010

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Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

ChemMedChem, 2012-08, Vol.7 (8), p.1385-1403

2012

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Utility of protein structures in overcoming ADMET-related issues of drug-like compounds

Drug discovery today, 2011-06, Vol.16 (11), p.530-538

2011

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Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban)

Current topics in medicinal chemistry, 2010-02, Vol.10 (3), p.257

2010

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Binding Free Energy Calculations for Lead Optimization: Assessment of Their Accuracy in an Industrial Drug Design Context

Journal of chemical theory and computation, 2014-08, Vol.10 (8), p.3331-3344

2014

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Conception and pharmacodynamic profile of drospirenone

Steroids, 2003-11, Vol.68 (10), p.891-905

2003

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Impact of Isotype-Selective Estrogen Receptor Agonists on Ovarian Function

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (14), p.5129-5134

2004

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Computational Chemistry in the Pharmaceutical Industry: From Childhood to Adolescence

ChemMedChem, 2015-12, Vol.10 (12), p.1958-1962

2015

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Bayer’s in silico ADMET platform: a journey of machine learning over the past two decades

Drug discovery today, 2020-09, Vol.25 (9), p.1702-1709

2020

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An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer — against all odds?

Drug discovery today, 2019-03, Vol.24 (3), p.668-672

2019

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Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting

ChemMedChem, 2020-11, Vol.15 (21), p.2010-2018

2020

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Prediction of Oral Bioavailability in Rats: Transferring Insights from in Vitro Correlations to (Deep) Machine Learning Models Using in Silico Model Outputs and Chemical Structure Parameters

Journal of chemical information and modeling, 2019-11, Vol.59 (11), p.4893-4905

2019

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Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico p K a Prediction

Journal of chemical information and modeling, 2015-02, Vol.55 (2), p.389-397

2015

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Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)

ChemMedChem, 2020-11, Vol.15 (21), p.1956-1956

2020

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Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pK a Prediction

Journal of chemical information and modeling, 2015-02, Vol.55 (2), p.389-397

2015

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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12574-12594

2020

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The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

ChemMedChem, 2013-07, Vol.8 (7), p.1067-1085

2013

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Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling

Chemical science (Cambridge), 2023-10, Vol.14 (41), p.11499-1156

2023

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Reliable and Performant Identification of Low-Energy Conformers in the Gas Phase and Water

Journal of chemical information and modeling, 2018-05, Vol.58 (5), p.1005-1020

2018

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Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12203-12224

2023

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Rendezvous in chemical space? Comparing the small molecule compound libraries of Bayer and Schering

Drug discovery today, 2011-07, Vol.16 (13), p.636-641

2011

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Solution Structure of a Five-Adenine Bulge Loop within a DNA Duplex

Biochemistry (Easton), 1999-09, Vol.38 (39), p.12860-12868

1999

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Oral, Direct Thrombin and Factor Xa Inhibitors: The Replacement for Warfarin, Leeches, and Pig Intestines?

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

Utility of homology models in the drug discovery process

A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

Utility of protein structures in overcoming ADMET-related issues of drug-like compounds

Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban)

Binding Free Energy Calculations for Lead Optimization: Assessment of Their Accuracy in an Industrial Drug Design Context

Conception and pharmacodynamic profile of drospirenone

Impact of Isotype-Selective Estrogen Receptor Agonists on Ovarian Function

Computational Chemistry in the Pharmaceutical Industry: From Childhood to Adolescence

Bayer’s in silico ADMET platform: a journey of machine learning over the past two decades

An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer — against all odds?

Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting

Prediction of Oral Bioavailability in Rats: Transferring Insights from in Vitro Correlations to (Deep) Machine Learning Models Using in Silico Model Outputs and Chemical Structure Parameters

Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico p K a Prediction

Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)

Best of Both Worlds: Combining Pharma Data and State of the Art Modeling Technology To Improve in Silico pK a Prediction

Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics

The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer

Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling

Reliable and Performant Identification of Low-Energy Conformers in the Gas Phase and Water

Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders

Rendezvous in chemical space? Comparing the small molecule compound libraries of Bayer and Schering

Solution Structure of a Five-Adenine Bulge Loop within a DNA Duplex

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