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Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

The Journal of immunology (1950), 2014-02, Vol.192 (3), p.1100-1106

2014

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Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

Nature structural & molecular biology, 2011-11, Vol.18 (11), p.1235-1243

2011

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Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Nature (London), 2021-05, Vol.593 (7857), p.130-135

2021

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The antigenic structure of the HIV gp120 envelope glycoprotein

Nature (London), 1998-06, Vol.393 (6686), p.705-711

1998

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Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

Journal of Virology, 2010-03, Vol.84 (6), p.2972-2982

2010

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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Nature (London), 2014-11, Vol.515 (7525), p.138-142

2014

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Nature (London), 2012-11, Vol.491 (7424), p.406-412

2012

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Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

Journal of virology, 2015-08, Vol.89 (16), p.8334-8345

2015

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Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

Journal of molecular biology, 2008-10, Vol.382 (2), p.510-524

2008

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Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Cell reports (Cambridge), 2018-10, Vol.25 (4), p.893-908.e7

2018

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Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

Science (American Association for the Advancement of Science), 2011-10, Vol.334 (6054), p.373-376

2011

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A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

Science (American Association for the Advancement of Science), 1998-06, Vol.280 (5371), p.1949-1953

1998

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Considerations on the Folding Topology and Evolutionary Origin of Cadherin Domains

Proceedings of the National Academy of Sciences - PNAS, 1995-07, Vol.92 (15), p.6793-6797

1995

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Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

Cell, 2014-07, Vol.158 (3), p.481-491

2014

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Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Nature structural & molecular biology, 2015-07, Vol.22 (7), p.522-531

2015

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Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

Proteins, structure, function, and bioinformatics, 2015-03, Vol.83 (3), p.590-596

2015

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Crystal structure of an HIV-binding recombinant fragment of human CD4

Nature (London), 1990-11, Vol.348 (6300), p.419-426

1990

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Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Journal of Virology, 2010-08, Vol.84 (16), p.8098-8110

2010

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Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

Journal of Virology, 2011-07, Vol.85 (13), p.6687-6701

2011

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Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

Nature chemical biology, 2017-10, Vol.13 (10), p.1115-1122

2017

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Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

Journal of molecular biology, 2011-06, Vol.409 (5), p.853-866

2011

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Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4764-4775

2012

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Amino Acid Sequence
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Molecular Sequence Data
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Antibodies, Neutralizing - Immunology
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Crystallography, X-Ray
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Protein Conformation
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Hiv
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Human Immunodeficiency Virus
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Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

The antigenic structure of the HIV gp120 envelope glycoprotein

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

Considerations on the Folding Topology and Evolutionary Origin of Cadherin Domains

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262

Crystal structure of an HIV-binding recombinant fragment of human CD4

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1

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