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Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

ACS nano, 2015-09, Vol.9 (9), p.9217-9227

2015

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Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Accounts of chemical research, 2014-04, Vol.47 (4), p.1228-1237

2014

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Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

PLoS pathogens, 2021-12, Vol.17 (12), p.e1010133-e1010133

2021

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Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4382-4396

2012

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The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Nature communications, 2017-10, Vol.8 (1), p.1049-12, Article 1049

2017

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Conformational stability and self-association equilibrium in biologics

Drug discovery today, 2016-02, Vol.21 (2), p.342-347

2016

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Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry Inhibition

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.330-334

2016

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CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies

Journal of virology, 2014-06, Vol.88 (12), p.6542-6555

2014

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Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (30), p.12283-12288

2009

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Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry

Analytical biochemistry, 2018-08, Vol.554, p.61-69

2018

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Reversibility and irreversibility in the temperature denaturation of monoclonal antibodies

Analytical biochemistry, 2021-08, Vol.626, p.114240-114240, Article 114240

2021

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Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

Molecular biology of the cell, 2013-11, Vol.24 (22), p.3522-3533

2013

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Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

Nature communications, 2023-11, Vol.14 (1), p.7593-7593, Article 7593

2023

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Thermodynamics of Binding of a Low-Molecular-Weight CD4 Mimetic to HIV-1 gp120

Biochemistry (Easton), 2006-09, Vol.45 (36), p.10973-10980

2006

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Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

Scientific reports, 2020-02, Vol.10 (1), p.3032-3032, Article 3032

2020

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Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

npj vaccines, 2020-12, Vol.5 (1), p.110-110, Article 110

2020

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Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

JCI insight, 2021-02, Vol.6 (3)

2021

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Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

European journal of medicinal chemistry, 2013-07, Vol.65, p.436-447

2013

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Structure-Based Design and Synthesis of an HIV‑1 Entry Inhibitor Exploiting X‑ray and Thermodynamic Characterization

ACS medicinal chemistry letters, 2013-03, Vol.4 (3), p.338-343

2013

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Optimization of CD4/gp120 Inhibitors by Thermodynamic-Guided Alanine-Scanning Mutagenesis

Chemical biology & drug design, 2013-01, Vol.81 (1), p.72-78

2013

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Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry

Proteins, structure, function, and bioinformatics, 2017-11, Vol.85 (11), p.2009-2016

2017

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Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

Journal of Virology, 2012-08, Vol.86 (16), p.8472-8481

2012

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Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions

Future medicinal chemistry, 2011-07, Vol.3 (9), p.1129

2011

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Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

Journal of Virology, 2009-09, Vol.83 (17), p.8364-8378

2009

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Enthalpy screen of drug candidates

Analytical biochemistry, 2016-11, Vol.513, p.1-6

2016

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Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Conformational stability and self-association equilibrium in biologics

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV‑1 Entry Inhibition

CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry

Reversibility and irreversibility in the temperature denaturation of monoclonal antibodies

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site

Thermodynamics of Binding of a Low-Molecular-Weight CD4 Mimetic to HIV-1 gp120

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study

Structure-Based Design and Synthesis of an HIV‑1 Entry Inhibitor Exploiting X‑ray and Thermodynamic Characterization

Optimization of CD4/gp120 Inhibitors by Thermodynamic-Guided Alanine-Scanning Mutagenesis

Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry

Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions

Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

Enthalpy screen of drug candidates

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