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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Journal of clinical oncology, 2019-03, Vol.37 (9), p.741-750

2019

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Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.1788-1804.e13

2019

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The PI3K AKT Pathway as a Target for Cancer Treatment

Annual review of medicine, 2016-01, Vol.67 (1), p.11-28

2016

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Immunity (Cambridge, Mass.), 2021-05, Vol.54 (5), p.976-987.e7

2021

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

American journal of respiratory cell and molecular biology, 2017-01, Vol.56 (1), p.74-82

2017

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A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella

Cell host & microbe, 2018-08, Vol.24 (2), p.285-295.e8

2018

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Daily exposure to Di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice

Biology of reproduction, 2014-06, Vol.90 (6), p.136

2014

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Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis

Gastroenterology (New York, N.Y. 1943), 2017-06, Vol.152 (8), p.1985-1997.e12

2017

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Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes

Environmental pollution (1987), 2018-03, Vol.234, p.406-419

2018

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Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

Chemico-biological interactions, 2024-05, Vol.394, p.110968-110968, Article 110968

2024

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High-Mobility Group Box 1 (HMGB1) Promotes Angiogenesis and Tumor Migration by Regulating Hypoxia-Inducible Factor 1 (HIF-1α) Expression via the Phosphatidylinositol 3-Kinase (PI3K)/AKT Signaling Pathway in Breast Cancer Cells

Medical science monitor, 2019-04, Vol.25, p.2352-2360

2019

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Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

The Journal of immunology (1950), 2020-07, Vol.205 (1), p.78-89

2020

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

The oncologist (Dayton, Ohio), 2011-01, Vol.16 (4), p.404-414

2011

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G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

The Journal of biological chemistry, 2016-12, Vol.291 (53), p.27160-27169

2016

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Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

Journal of clinical oncology, 2014-09, Vol.32 (25), p.2794-2803

2014

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Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

European journal of vascular and endovascular surgery, 2020-08, Vol.60 (2), p.254-263

2020

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TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α

Cellular signalling, 2016-03, Vol.28 (3), p.148-156

2016

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Insulin Receptor Substrate 2-mediated Phosphatidylinositol 3-kinase Signaling Selectively Inhibits Glycogen Synthase Kinase 3β to Regulate Aerobic Glycolysis

The Journal of biological chemistry, 2014-06, Vol.289 (26), p.18603-18613

2014

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Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

Breast cancer research and treatment, 2018-06, Vol.169 (3), p.397-406

2018

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Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation

The Journal of biological chemistry, 2016-02, Vol.291 (9), p.4547-4560

2016

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Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis

Molecular and cellular biology, 2014-04, Vol.34 (7), p.1363-1377

2014

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

The PI3K AKT Pathway as a Target for Cancer Treatment

PI3Kγ is a molecular switch that controls immune suppression

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella

Daily exposure to Di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice

Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis

Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes

Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

High-Mobility Group Box 1 (HMGB1) Promotes Angiogenesis and Tumor Migration by Regulating Hypoxia-Inducible Factor 1 (HIF-1α) Expression via the Phosphatidylinositol 3-Kinase (PI3K)/AKT Signaling Pathway in Breast Cancer Cells

Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Targeting the Phosphatidylinositol 3‐Kinase Signaling Pathway in Breast Cancer

G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway

Luminal B breast cancer: molecular characterization, clinical management, and future perspectives

Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α

Insulin Receptor Substrate 2-mediated Phosphatidylinositol 3-kinase Signaling Selectively Inhibits Glycogen Synthase Kinase 3β to Regulate Aerobic Glycolysis

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation

Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis

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