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OP0204 Characterization of the novel C5AR antagonist CCX168, a potential therapeutic for ANCA-vasculitis, rheumatoid arthritis, and other autoimmune disorders

Annals of the rheumatic diseases, 2013-06, Vol.71 (Suppl 3), p.124-124

2013

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Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5686-5691

1999

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2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1060-1067

1998

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Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1843-1846

1999

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Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

The Journal of biological chemistry, 1999-08, Vol.274 (32), p.22805-22812

1999

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Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3599-3605

2001

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Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2653-2656

1998

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Advances in the Discovery of C5a Receptor Antagonists

Annual Reports in Medicinal Chemistry, 2011, Vol.46, p.171-186

2011

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4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties

Journal of medicinal chemistry, 1990-01, Vol.33 (1), p.311-317

1990

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Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2524-2536

1998

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Acetylcholinesterase inhibition by fused dihydroquinazoline compounds

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.737-742

1996

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Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3179-3187

1996

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Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.679-682

1996

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Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4439-4445

1995

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2-(1,3,5-Dithiazinan-5-yl)ethanol Heterocycles, Structure and Reactivity

Heterocycles, 2004-10, Vol.63 (10), p.2269

2004

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Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and .sigma. receptors

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3929-3936

1993

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Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.3014-3018

1996

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Characterization of muscarinic agonists in recombinant cell lines

Life sciences (1973), 1993, Vol.52 (5), p.465-472

1993

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Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.248-256

1991

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Dopamine autoreceptor agonists as potential antipsychotics. 3. 6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2736-2746

1991

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Synthesis of the enantiomers of reduced haloperidol

Pharmaceutical research, 1991-08, Vol.8 (8), p.1002-1005

1991

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EFFICIENT SYNTHESIS OF EXO-1-AZABICYCLO[2.2.1]HEPTAN-3-OL

Organic preparations and procedures international, 1997-06, Vol.29 (3), p.330-335

1997

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(±)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists

Bioorganic & medicinal chemistry letters, 1995-03, Vol.5 (6), p.637-642

1995

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Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes as potential m1-subtype selective muscarinic agonists

Bioorganic & medicinal chemistry letters, 1995-03, Vol.5 (6), p.631-636

1995

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Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers

The Journal of pharmacology and experimental therapeutics, 1993-09, Vol.266 (3), p.1177

1993

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OP0204 Characterization of the novel C5AR antagonist CCX168, a potential therapeutic for ANCA-vasculitis, rheumatoid arthritis, and other autoimmune disorders

Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease

Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Advances in the Discovery of C5a Receptor Antagonists

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties

Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist

Acetylcholinesterase inhibition by fused dihydroquinazoline compounds

Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships

Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor

2-(1,3,5-Dithiazinan-5-yl)ethanol Heterocycles, Structure and Reactivity

Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and .sigma. receptors

Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Characterization of muscarinic agonists in recombinant cell lines

Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones

Dopamine autoreceptor agonists as potential antipsychotics. 3. 6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine

Synthesis of the enantiomers of reduced haloperidol

EFFICIENT SYNTHESIS OF EXO-1-AZABICYCLO[2.2.1]HEPTAN-3-OL

(±)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists

Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes as potential m1-subtype selective muscarinic agonists

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers

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