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Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose

Clinical pharmacology and therapeutics, 2011-05, Vol.89 (5), p.726-734

2011

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Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

British journal of cancer, 2014-03, Vol.110 (5), p.1179-1188

2014

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2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1060-1067

1998

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Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1843-1846

1999

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Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3599-3605

2001

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FRI0002 Inhibition of chemokine receptors ccr1 and ccr6 as promising therapies for rheumatoid arthritis

Annals of the rheumatic diseases, 2013-06, Vol.72 (Suppl 3), p.A369-A369

2013

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Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2653-2656

1998

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Chemical Cosmology

Boeyens, Jan C. A

1. Aufl., 2010

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Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5686-5691

1999

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Identification and characterization of m4 selective muscarinic antagonists

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (15), p.1991-1996

1998

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Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

The Journal of biological chemistry, 1999-08, Vol.274 (32), p.22805-22812

1999

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Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3179-3187

1996

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Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4439-4445

1995

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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Blood, 2012-08, Vol.120 (7), p.1449-1457

2012

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Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and .sigma. receptors

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3929-3936

1993

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The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents

Journal of medicinal chemistry, , Vol.37 (21), p.3523-3533

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Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.3014-3018

1996

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Characterization of muscarinic agonists in recombinant cell lines

Life sciences (1973), 1993, Vol.52 (5), p.465-472

1993

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Synthesis and dopamine agonist properties of (+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol and its enantiomers

Journal of medicinal chemistry, 1990-01, Vol.33 (1), p.445-450

1990

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4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties

Journal of medicinal chemistry, 1990-01, Vol.33 (1), p.311-317

1990

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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.2842-2845

2006

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Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers

The Journal of pharmacology and experimental therapeutics, 1993-09, Vol.266 (3), p.1177

1993

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Synthesis of the enantiomers of reduced haloperidol

Pharmaceutical research, 1991-08, Vol.8 (8), p.1002-1005

1991

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Identification and Characterization of m1 Selective Muscarinic Receptor Antagonists

Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.356-363

1999

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Pharmacokinetic and Pharmacodynamic Evaluation of the Novel CCR1 Antagonist CCX354 in Healthy Human Subjects: Implications for Selection of Clinical Dose

Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease

Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier

FRI0002 Inhibition of chemokine receptors ccr1 and ccr6 as promising therapies for rheumatoid arthritis

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Chemical Cosmology

Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Identification and characterization of m4 selective muscarinic antagonists

Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist

Secreted Site-1 Protease Cleaves Peptides Corresponding to Luminal Loop of Sterol Regulatory Element-binding Proteins

Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure−Activity Relationships

Kynurenic Acid Derivatives Inhibit the Binding of Nerve Growth Factor (NGF) to the Low-Affinity p75 NGF Receptor

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and .sigma. receptors

The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents

Identification of a 3-Hydroxylated Tacrine Metabolite in Rat and Man: Metabolic Profiling Implications and Pharmacology

Characterization of muscarinic agonists in recombinant cell lines

Synthesis and dopamine agonist properties of (+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol and its enantiomers

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers

Synthesis of the enantiomers of reduced haloperidol

Identification and Characterization of m1 Selective Muscarinic Receptor Antagonists

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