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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Journal of molecular biology, 2020-11, Vol.432 (22), p.5849-5859

2020

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1-12

2021

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PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8559-8581

2012

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Duvelisib for the treatment of chronic lymphocytic leukemia

Expert opinion on pharmacotherapy, 2020-07, Vol.21 (11), p.1299-1309

2020

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Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6527), p.405-410

2021

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Mechanisms of Autophagy Initiation

Annual review of biochemistry, 2017-06, Vol.86 (1), p.225-244

2017

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Phosphatidylinositol 3‑Kinase (PI3K) and Phosphatidylinositol 3‑Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.41-71

2015

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Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.1788-1804.e13

2019

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Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Journal of clinical oncology, 2019-03, Vol.37 (9), p.741-750

2019

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in cancer biology, 2022-05, Vol.80, p.1-17

2022

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Architecture and activation of phosphatidylinositol 3-kinase related kinases

Current opinion in structural biology, 2018-04, Vol.49, p.177-189

2018

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The PI3K AKT Pathway as a Target for Cancer Treatment

Annual review of medicine, 2016-01, Vol.67 (1), p.11-28

2016

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Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

Artificial organs, 2013-03, Vol.37 (3), p.298-307

2013

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Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Medicinal research reviews, 2021-05, Vol.41 (3), p.1599-1621

2021

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Immunity (Cambridge, Mass.), 2021-05, Vol.54 (5), p.976-987.e7

2021

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Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.155-161

2011

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Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Journal of neuroinflammation, 2021-11, Vol.18 (1), p.276-276, Article 276

2021

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Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

The Journal of biological chemistry, 2015-07, Vol.290 (28), p.17495-17504

2015

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Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Cellular signalling, 2023-08, Vol.108, p.110693-110693, Article 110693

2023

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Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

eLife, 2014-11, Vol.3, p.e04135-e04135

2014

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Journal of Virology, 2013-03, Vol.87 (5), p.2508-2517

2013

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Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

International journal of biological macromolecules, 2020-12, Vol.164, p.456-467

2020

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Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

American journal of respiratory cell and molecular biology, 2017-01, Vol.56 (1), p.74-82

2017

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Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway

World journal of gastroenterology : WJG, 2024-07, Vol.30 (26), p.3206-3209

2024

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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

Duvelisib for the treatment of chronic lymphocytic leukemia

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Mechanisms of Autophagy Initiation

Phosphatidylinositol 3‑Kinase (PI3K) and Phosphatidylinositol 3‑Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Architecture and activation of phosphatidylinositol 3-kinase related kinases

The PI3K AKT Pathway as a Target for Cancer Treatment

Inhibition of the PI3K/AKT Pathway Reduces Tumor Necrosis Factor-Alpha Production in the Cellular Response to Wear Particles In Vitro

Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4 + T Cell Proliferation

Tumor-related factor complement Clq/TNF-related protein 6 affects the development of digestive system tumors through the phosphatidylinositol 3-kinase pathway

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