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Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1868-1897

2012

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Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1789-1811

2011

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Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9156-9169

2012

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Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2417-2430

2015

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Bornyl Diphosphate Synthase: Structure and Strategy for Carbocation Manipulation by a Terpenoid Cyclase

Proceedings of the National Academy of Sciences - PNAS, 2002-11, Vol.99 (24), p.15375-15380

2002

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2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex

Inorganic chemistry, 2001-10, Vol.40 (22), p.5596-5602

2001

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Crystal Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) Demonstrating Geometrical Variability at the Dinuclear Iron Active Site

Journal of the American Chemical Society, 2001-02, Vol.123 (5), p.827-838

2001

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Next generation Fc scaffold for multispecific antibodies

iScience, 2021-12, Vol.24 (12), p.103447-103447, Article 103447

2021

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Crystal Structure of the Dimeric Extracellular Domain of Human Carbonic Anhydrase XII, A Bitopic Membrane Protein Overexpressed in Certain Cancer Tumor Cells

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (17), p.9545-9550

2001

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Crystal Structure of LpxC, a Zinc-Dependent Deacetylase Essential for Endotoxin Biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2003-07, Vol.100 (14), p.8146-8150

2003

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PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8559-8581

2012

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The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

The Journal of biological chemistry, 2012-10, Vol.287 (44), p.37447-37457

2012

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Discovery of AM-6494: A Potent and Orally Efficacious β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2263-2281

2020

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Large Scale ab Initio Quantum Chemical Calculation of the Intermediates in the Soluble Methane Monooxygenase Catalytic Cycle

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2828-2839

2000

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UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism

The Journal of biological chemistry, 2005-04, Vol.280 (17), p.16969-16978

2005

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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers

Journal of medicinal chemistry, 2024-04

2024

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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Molecular cancer therapeutics, 2023-02, Vol.22 (2), p.215-226

2023

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Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit

Journal of medicinal chemistry, 2008-06, Vol.51 (11), p.3065-3068

2008

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Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Activation of the C−H Bond of Methane by Intermediate Q of Methane Monooxygenase: A Theoretical Study

Journal of the American Chemical Society, 2001-04, Vol.123 (16), p.3836-3837

2001

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.480-511

2015

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Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)‑7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H‑spiro[chromeno[2,3‑b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9811-9831

2014

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Xenon and Halogenated Alkanes Track Putative Substrate Binding Cavities in the Soluble Methane Monooxygenase Hydroxylase

Biochemistry (Easton), 2001-03, Vol.40 (12), p.3476-3482

2001

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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (14), p.127240-127240, Article 127240

2020

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Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Bornyl Diphosphate Synthase: Structure and Strategy for Carbocation Manipulation by a Terpenoid Cyclase

2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex

Crystal Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) Demonstrating Geometrical Variability at the Dinuclear Iron Active Site

Next generation Fc scaffold for multispecific antibodies

Crystal Structure of the Dimeric Extracellular Domain of Human Carbonic Anhydrase XII, A Bitopic Membrane Protein Overexpressed in Certain Cancer Tumor Cells

Crystal Structure of LpxC, a Zinc-Dependent Deacetylase Essential for Endotoxin Biosynthesis

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases

The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

Discovery of AM-6494: A Potent and Orally Efficacious β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

Large Scale ab Initio Quantum Chemical Calculation of the Intermediates in the Soluble Methane Monooxygenase Catalytic Cycle

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit

Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Activation of the C−H Bond of Methane by Intermediate Q of Methane Monooxygenase: A Theoretical Study

Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)‑7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H‑spiro[chromeno[2,3‑b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Xenon and Halogenated Alkanes Track Putative Substrate Binding Cavities in the Soluble Methane Monooxygenase Hydroxylase

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement

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