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Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation

European journal of medicinal chemistry, 2018-08, Vol.156, p.800-814

2018

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SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors

Bioorganic & medicinal chemistry letters, 2021-09, Vol.47, p.128214-128214, Article 128214

2021

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115213, Article 115213

2020

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Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

European journal of medicinal chemistry, 2019-02, Vol.163, p.649-659

2019

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Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors

European journal of medicinal chemistry, 2018-09, Vol.157, p.1361-1375

2018

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Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

Bioorganic & medicinal chemistry, 2015-11, Vol.23 (21), p.6844-6854

2015

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Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (11), p.127143-127143, Article 127143

2020

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Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance

European journal of medicinal chemistry, 2019-10, Vol.180, p.350-366

2019

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Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (21), p.3446-3453

2018

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1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity

European journal of medicinal chemistry, 2021-12, Vol.226, p.113873-113873, Article 113873

2021

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Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors

Bioorganic chemistry, 2020-12, Vol.105, p.104447, Article 104447

2020

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N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors

European journal of medicinal chemistry, 2023-05, Vol.251, p.115227-115227, Article 115227

2023

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Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Bioorganic & medicinal chemistry, 2018-08, Vol.26 (14), p.4209-4224

2018

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Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1443-1451

2016

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Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives

Bioorganic & medicinal chemistry, 2018-08, Vol.26 (15), p.4452-4460

2018

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Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo

European journal of medicinal chemistry, 2018-05, Vol.151, p.261-271

2018

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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1283-1291

2019

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Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2021-01, Vol.31, p.127696-127696, Article 127696

2021

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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2021-09, Vol.47, p.128168-128168, Article 128168

2021

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Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease

European journal of medicinal chemistry, 2019-08, Vol.175, p.63-71

2019

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Synthesis and biological evaluation of novel aromatic amide derivatives as potential BCR-ABL inhibitors

Bioorganic & medicinal chemistry letters, 2023-02, Vol.81, p.129144-129144, Article 129144

2023

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Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses

Bioorganic & medicinal chemistry letters, 2023-01, Vol.79, p.129080-129080, Article 129080

2023

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Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2752-2756

2017

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Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines

European journal of medicinal chemistry, 2019-12, Vol.183, p.111708-111708, Article 111708

2019

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Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation

SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening

Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors

Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives

Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors

1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity

Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors

N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives

Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease

Synthesis and biological evaluation of novel aromatic amide derivatives as potential BCR-ABL inhibitors

Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses

Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F

Exploration of the antibiotic potentiating activity of indolglyoxylpolyamines

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