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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

The Journal of biological chemistry, 2018-05, Vol.293 (18), p.7040-7057

2018

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COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.265

2021

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Phenytoin and phenobarbital inhibit human HERG potassium channels

Epilepsy research, 2003, Vol.55 (1), p.147-157

2003

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Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

Biochemical and biophysical research communications, 2020-11, Vol.532 (2), p.265-270

2020

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8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Journal of ethnopharmacology, 2021-08, Vol.276, p.114168-114168, Article 114168

2021

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An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126681, Article 126681

2019

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A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

British journal of pharmacology, 2017-12, Vol.174 (23), p.4396-4408

2017

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Regulation of ion channel localization and phosphorylation by neuronal activity

Nature neuroscience, 2004-07, Vol.7 (7), p.711-718

2004

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Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

The Journal of pharmacology and experimental therapeutics, 2012-09, Vol.342 (3), p.642

2012

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A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Angewandte Chemie International Edition, 2017-09, Vol.56 (38), p.11520-11524

International ed. in English, 2017

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Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

Organic letters, 2016-05, Vol.18 (9), p.2166-2169

2016

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A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

FEBS letters, 2012-11, Vol.586 (22), p.3996-4001

2012

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ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

Experimental neurology, 2012-05, Vol.235 (1), p.282-296

2012

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A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs

The Journal of biological chemistry, 2021-01, Vol.296, p.100302-100302, Article 100302

2021

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Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

The Journal of neuroscience, 2009-06, Vol.29 (23), p.7474-7488

2009

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Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels

Circulation research, 2009-04, Vol.104 (8), p.987-994

2009

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Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Journal of molecular and cellular cardiology, 2015-08, Vol.85, p.71-78

2015

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Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

The Journal of neuroscience, 2015-09, Vol.35 (38), p.13206-13218

2015

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Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

Circulation research, 2012-01, Vol.110 (2), p.285-294

2012

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Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

The Journal of neuroscience, 2010-01, Vol.30 (2), p.491-504

2010

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Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Arteriosclerosis, thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2404

2016

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Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels

European journal of medicinal chemistry, 2017-10, Vol.139, p.232-241

2017

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Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation

Circulation. Arrhythmia and electrophysiology, 2011-02, Vol.4 (1), p.94-102

2011

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Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1

Pharmacological reports, 2021-12, Vol.73 (6), p.1744-1753

2021

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker

COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Phenytoin and phenobarbital inhibit human HERG potassium channels

Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

Regulation of ion channel localization and phosphorylation by neuronal activity

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease

A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

A high-affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs

Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

Acidosis Dilates Brain Parenchymal Arterioles by Conversion of Calcium Waves to Sparks to Activate BK Channels

Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels

Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation

Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1

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