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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

Biological psychiatry (1969), 2018-11, Vol.84 (10), p.722-733

2018

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Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Journal of neuroinflammation, 2021-04, Vol.18 (1), p.99-99, Article 99

2021

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Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10820

2022

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Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Molecules (Basel, Switzerland), 2020-01, Vol.25 (2), p.417

2020

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Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors

PloS one, 2014-10, Vol.9 (10), p.e109115-e109115

2014

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Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Frontiers in molecular neuroscience, 2020-04, Vol.13, p.54-54

2020

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The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Molecular pain, 2012-09, Vol.8 (1), p.71-71

2012

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Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Frontiers in neuroscience, 2023-06, Vol.17, p.1196786-1196786

2023

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Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in pharmacology, 2022-10, Vol.13, p.919605-919605

2022

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Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.584

2008

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Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Molecular pain, 2014-04, Vol.10 (1), p.27-27

2014

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Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

Brain and behavior, 2020-12, Vol.10 (12), p.e01850-n/a

2020

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Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in molecular neuroscience, 2019-10, Vol.12, p.257-257

2019

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Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

Journal of organic chemistry, 2017-01, Vol.82 (2), p.992-999

2017

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The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO neuroscience reports, 2022-06, Vol.12, p.121-130

2022

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Conformationally constrained analogs of BAY 59–3074 as novel cannabinoid receptor ligands

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5999-6002

2011

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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Antioxidants, 2021-01, Vol.10 (1), p.135

2021

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C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5322-5325

2012

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Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7

Molecular pharmacology, 2007-06, Vol.71 (6), p.1512-1524

2007

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Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder

Neuropsychopharmacology (New York, N.Y.), 2018-01, Vol.43 (1), p.226-227

2018

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Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG

Brain research, 2022-01, Vol.1774, p.147721-147721, Article 147721

2022

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Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site

Molecular pharmacology, 2019-06, Vol.95 (6), p.606-614

2019

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Differential Activation and Desensitization States Promoted by Noncanonical α 7 Nicotinic Acetylcholine Receptor Agonists

The Journal of pharmacology and experimental therapeutics, 2022-11, Vol.383 (2), p.157-171

2022

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Unprecedented, catalyst‐free, and rapid one‐pot, three‐component green synthesis of substituted 3‐hydroxy‐2‐oxindoles in water

Journal of heterocyclic chemistry, 2023-12, Vol.60 (12), p.2063-2071

2023

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Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.665-681

2015

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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors

Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

Conformationally constrained analogs of BAY 59–3074 as novel cannabinoid receptor ligands

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor

Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7

Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder

Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG

Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site

Differential Activation and Desensitization States Promoted by Noncanonical α 7 Nicotinic Acetylcholine Receptor Agonists

Unprecedented, catalyst‐free, and rapid one‐pot, three‐component green synthesis of substituted 3‐hydroxy‐2‐oxindoles in water

Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols

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