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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

British journal of pharmacology, 2016-08, Vol.173 (16), p.2506-2520

2016

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Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Journal of neuroinflammation, 2021-04, Vol.18 (1), p.99-99, Article 99

2021

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Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10820

2022

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Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors

PloS one, 2014-10, Vol.9 (10), p.e109115-e109115

2014

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Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation

Molecules (Basel, Switzerland), 2020-01, Vol.25 (2), p.417

2020

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Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Frontiers in molecular neuroscience, 2020-04, Vol.13, p.54-54

2020

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The Maintenance of Cisplatin- and Paclitaxel-Induced Mechanical and Cold Allodynia is Suppressed by Cannabinoid CB2 Receptor Activation and Independent of CXCR4 Signaling in Models of Chemotherapy-Induced Peripheral Neuropathy

Molecular pain, 2012-09, Vol.8 (1), p.71-71

2012

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Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Frontiers in neuroscience, 2023-06, Vol.17, p.1196786-1196786

2023

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Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Frontiers in pharmacology, 2022-10, Vol.13, p.919605-919605

2022

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Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

The Journal of pharmacology and experimental therapeutics, 2008-11, Vol.327 (2), p.584

2008

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Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Molecular pain, 2014-04, Vol.10 (1), p.27-27

2014

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Peripheral versus central mechanisms of the cannabinoid type 2 receptor agonist AM1710 in a mouse model of neuropathic pain

Brain and behavior, 2020-12, Vol.10 (12), p.e01850-n/a

2020

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Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Frontiers in molecular neuroscience, 2019-10, Vol.12, p.257-257

2019

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Scalable, One-Pot, Microwave-Accelerated Tandem Synthesis of Unsymmetrical Urea Derivatives

Journal of organic chemistry, 2017-01, Vol.82 (2), p.992-999

2017

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The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg

IBRO neuroscience reports, 2022-06, Vol.12, p.121-130

2022

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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Antioxidants, 2021-01, Vol.10 (1), p.135

2021

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Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder

Neuropsychopharmacology (New York, N.Y.), 2018-01, Vol.43 (1), p.226-227

2018

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Differential Activation and Desensitization States Promoted by Noncanonical α 7 Nicotinic Acetylcholine Receptor Agonists

The Journal of pharmacology and experimental therapeutics, 2022-11, Vol.383 (2), p.157

2022

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Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site

Molecular pharmacology, 2019-06, Vol.95 (6), p.606-614

2019

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The [alpha]7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

British journal of pharmacology, 2016-08, Vol.173 (16), p.2506-2520

2016

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Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.665-681

2015

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Negative allosteric modulation of CB1 cannabinoid receptor signalling decreases intravenous morphine self‐administration and relapse in mice

Addiction biology, 2024-08, Vol.29 (8), p.e13429-n/a

2024

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Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107

Molecular pharmacology, 2019-01, Vol.95 (1), p.43-61

2019

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Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction

The Journal of pharmacology and experimental therapeutics, 2008-04, Vol.325 (1), p.341

2008

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Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION

The Journal of biological chemistry, 2016-03, Vol.291 (10), p.5049-5067

2016

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