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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

The Journal of biological chemistry, 2009-06, Vol.284 (25), p.16998-17005

2009

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The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice

PloS one, 2020-01, Vol.15 (1), p.e0227715-e0227715

2020

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The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate

PloS one, 2019-02, Vol.14 (2), p.e0211746-e0211746

2019

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Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

American journal of physiology. Heart and circulatory physiology, 2007-09, Vol.293 (3), p.H1654-H1661

2007

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Structural Basis for the Non-Immunosuppressive Character of the Cyclosporin A Analogue Debio 025

Biochemistry (Easton), 2010-06, Vol.49 (22), p.4679-4686

2010

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Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

Clinical and translational science, 2022-01, Vol.15 (1), p.55-62

2022

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A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes

The Journal of biological chemistry, 2007-01, Vol.282 (1), p.58-64

2007

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The cyclophilin inhibitor alisporivir as a candidate to reduce muscular dystrophy pathology

Biochimica et biophysica acta. Bioenergetics, 2016-08, Vol.1857, p.e19-e20

Vuagniaux, Gregoire

2016

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Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

Antimicrobial Agents and Chemotherapy, 2009-03, Vol.53 (3), p.967-976

2009

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ENaC‐mediated alveolar fluid clearance and lung fluid balance depend on the channel‐activating protease 1

EMBO molecular medicine, 2010-01, Vol.2 (1), p.26-37

2010

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DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death

Scientific reports, 2018-12, Vol.8 (1), p.17862-12, Article 17862

2018

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SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer

Clinical cancer research, 2019-02, Vol.25 (3), p.1113-1124

2019

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In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases

American journal of physiology. Lung cellular and molecular physiology, 2005-06, Vol.288 (6), p.L1099-L1109

2005

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A near-full length genotypic assay for HCV1b

Journal of virological methods, 2014-12, Vol.209, p.126-135

2014

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DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

PloS one, 2010-10, Vol.5 (10), p.e13687

2010

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

Nature medicine, 2008-04, Vol.14 (4), p.442-447

2008

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A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome

Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.4264-4273

2016

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Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model

Contrast media and molecular imaging, 2018-01, Vol.2018, p.8494031-11

2018

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The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction

Hepatology (Baltimore, Md.), 2012-05, Vol.55 (5), p.1333-1343

2012

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The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma

Radiotherapy and oncology, 2015-09, Vol.116 (3), p.495-503

2015

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Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms

Viruses, 2013-03, Vol.5 (3), p.981-997

2013

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Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis

Arthritis research & therapy, 2009-01, Vol.11 (6), p.R195-R195

2009

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Cyclophilin Inhibitors Block Arterivirus Replication by Interfering with Viral RNA Synthesis

Journal of Virology, 2013-02, Vol.87 (3), p.1454-1464

2013

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Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice

Neuromuscular disorders : NMD, 2010-11, Vol.20 (11), p.753-760

2010

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Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model

Acta dermato-venereologica, 2014-01, Vol.94 (6), p.672-676

2014

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice

The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate

Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

Structural Basis for the Non-Immunosuppressive Character of the Cyclosporin A Analogue Debio 025

Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

A Novel Neutrophil Elastase Inhibitor Prevents Elastase Activation and Surface Cleavage of the Epithelial Sodium Channel Expressed in Xenopus laevis Oocytes

The cyclophilin inhibitor alisporivir as a candidate to reduce muscular dystrophy pathology

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

ENaC‐mediated alveolar fluid clearance and lung fluid balance depend on the channel‐activating protease 1

DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death

SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer

In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases

A near-full length genotypic assay for HCV1b

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome

Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model

The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction

The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma

Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms

Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis

Cyclophilin Inhibitors Block Arterivirus Replication by Interfering with Viral RNA Synthesis

Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice

Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model

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