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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

Gut, 2016-08, Vol.65 (8), p.1333-1346

2016

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Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

Circulation research, 2006-08, Vol.99 (4), p.407-414

2006

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Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

Clinical and translational science, 2022-01, Vol.15 (1), p.55-62

2022

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Cardiac Voltage-Gated Sodium Channel Nav1.5 Is Regulated by Nedd4-2 Mediated Ubiquitination

Circulation research, 2004-08, Vol.95 (3), p.284-291

2004

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Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

Toxicological sciences, 2010-11, Vol.118 (1), p.276-285

2010

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Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

American Journal of Physiology: Cell Physiology, 2005-03, Vol.288 (3), p.C692-C701

2005

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Aldosterone increases voltage-gated sodium current in ventricular myocytes

American journal of physiology. Heart and circulatory physiology, 2006-06, Vol.290 (6), p.H2257-H2266

2006

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Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

Circulation (New York, N.Y.), 2004-11, Vol.110 (19), p.3028-3035

2004

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Phase I Study of Androgen Deprivation Therapy in Combination with Anti-PD-1 in Melanoma Patients Pretreated with Anti-PD-1

Clinical cancer research, 2023-03, Vol.29 (5), p.858-865

2023

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The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction

Hepatology (Baltimore, Md.), 2012-05, Vol.55 (5), p.1333-1343

2012

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Abstract 4703: The inhibitor of apoptosis protein (IAP) antagonist Debio 1143 enhances the immune response to anti-PD1/L1 inhibitors in vitro and in vivo

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4703-4703

2018

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Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

Journal of molecular and cellular cardiology, 2011-07, Vol.51 (1), p.90-98

2011

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Abstract 3443: The IAP antagonist xevinapant, in combination with high-dose cisplatin chemoradiotherapy, induces NF-kB and apoptotic pathway biomarkers in patients with high-risk locally advanced squamous cell carcinoma of the head and neck

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3443-3443

2022

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Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model

Acta dermato-venereologica, 2014-01, Vol.94 (6), p.672-676

2014

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A dose-finding study of the SMAC mimetic Debio 1143 when given in combination with avelumab to patients with advanced solid malignancies

Journal of clinical oncology, 2019-05, Vol.37 (15_suppl), p.2599-2599

2019

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Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

Circulation research, 2009-03, Vol.104 (6), p.758-769

2009

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Abstract A93: The Smac mimetic Debio 1143 synergizes with radiotherapy and immune checkpoint inhibitors to enhance antitumor immunity

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A93-A93

2015

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Clinical pharmacokinetic (PK)/pharmacodynamic (PD) model for Debio 1143, a novel antagonist of IAPs in cancer treatment

Journal of clinical oncology, 2014-05, Vol.32 (15_suppl), p.2585-2585

2014

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Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice

Frontiers in physiology, 2013, Vol.4, p.51-51

2013

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Abstract C2: Clinical safety, pharmacokinetics and early evidence of activity of the oral IAPs inhibitor Debio 1143 in combination with carboplatin and paclitaxel: a phase Ib study

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C2-C2

2015

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Cardiac sodium channel Nav1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1

Biochemical and biophysical research communications, 2006-10, Vol.348 (4), p.1455-1462

2006

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Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice

Frontiers in physiology, 2013-03, Vol.4

2013

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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

Cardiac Voltage-Gated Sodium Channel Nav1.5 Is Regulated by Nedd4-2 Mediated Ubiquitination

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

Aldosterone increases voltage-gated sodium current in ventricular myocytes

Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

Phase I Study of Androgen Deprivation Therapy in Combination with Anti-PD-1 in Melanoma Patients Pretreated with Anti-PD-1

The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction

Abstract 4703: The inhibitor of apoptosis protein (IAP) antagonist Debio 1143 enhances the immune response to anti-PD1/L1 inhibitors in vitro and in vivo

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

Abstract 3443: The IAP antagonist xevinapant, in combination with high-dose cisplatin chemoradiotherapy, induces NF-kB and apoptotic pathway biomarkers in patients with high-risk locally advanced squamous cell carcinoma of the head and neck

Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model

Abstract 5001: Open-label, non-randomized, exploratory pre-operative window-of-opportunity trial to investigate the pharmacokinetics and pharmacodynamics of the smac mimetic Debio 1143 in patients with resectable squamous cell carcinoma of the head and neck

A dose-finding study of the SMAC mimetic Debio 1143 when given in combination with avelumab to patients with advanced solid malignancies

Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

Abstract A93: The Smac mimetic Debio 1143 synergizes with radiotherapy and immune checkpoint inhibitors to enhance antitumor immunity

Clinical pharmacokinetic (PK)/pharmacodynamic (PD) model for Debio 1143, a novel antagonist of IAPs in cancer treatment

Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice

Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a+/− Mouse Model

Abstract C2: Clinical safety, pharmacokinetics and early evidence of activity of the oral IAPs inhibitor Debio 1143 in combination with carboplatin and paclitaxel: a phase Ib study

Cardiac sodium channel Nav1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1

Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice

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