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Allosteric communication regulates ligand‐specific GPCR activity

The FEBS journal, 2021-04, Vol.288 (8), p.2502-2512

2021

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Variable G protein determinants of GPCR coupling selectivity

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.12054-12059

2019

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The role of conformational ensembles of seven transmembrane receptors in functional selectivity

Current opinion in pharmacology, 2010-12, Vol.10 (6), p.775-781

2010

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How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

Trends in pharmacological sciences (Regular ed.), 2016-01, Vol.37 (1), p.37-46

2016

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Conformational plasticity of the intracellular cavity of GPCR–G-protein complexes leads to G-protein promiscuity and selectivity

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.11956-11965

2019

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Human breast cancer metastases to the brain display GABAergic properties in the neural niche

Proceedings of the National Academy of Sciences - PNAS, 2014-01, Vol.111 (3), p.984-989

2014

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C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

Nature communications, 2018-06, Vol.9 (1), p.2484-14, Article 2484

2018

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Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Nature (London), 2021-01, Vol.589 (7840), p.148-153

2021

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Efficient and Selective Electrochemically Driven Enzyme-Catalyzed Reduction of Carbon Dioxide to Formate using Formate Dehydrogenase and an Artificial Cofactor

Accounts of chemical research, 2019-03, Vol.52 (3), p.676-685

2019

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Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors

Journal of chemical information and modeling, 2019-09, Vol.59 (9), p.3744-3754

2019

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How Do Short Chain Nonionic Detergents Destabilize G‑Protein-Coupled Receptors?

Journal of the American Chemical Society, 2016-11, Vol.138 (47), p.15425-15433

2016

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Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

Nature communications, 2022-12, Vol.13 (1), p.7428-7428, Article 7428

2022

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Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

Breast cancer research : BCR, 2017-04, Vol.19 (1), p.51-51, Article 51

2017

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Dynamic Spatiotemporal Determinants Modulate GPCR:G protein Coupling Promiscuity and Biased Signaling

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.03925

Vaidehi, Nagarajan

2021

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Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling

Science signaling, 2023-08, Vol.16 (797), p.eadf2173

2023

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Structure and dynamics of a constitutively active neurotensin receptor

Scientific reports, 2016-12, Vol.6 (1), p.38564-38564, Article 38564

2016

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Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (6), p.2957-2967

2020

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The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors

Journal of the American Chemical Society, 2011-08, Vol.133 (33), p.13197-13204

2011

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Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

The journal of physical chemistry. B, 2015-04, Vol.119 (15), p.4917-4928

2015

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Sulfation patterns of glycosaminoglycans encode molecular recognition and activity

Nature chemical biology, 2006-09, Vol.2 (9), p.467-473

2006

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N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.E3600-E3608

2015

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Catalytic site mutations confer multiple states of G protein activation

Science signaling, 2023-02, Vol.16 (772), p.eabq7842

2023

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Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

Structure (London), 2019-04, Vol.27 (4), p.703-712.e3

2019

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Differences in Allosteric Communication Pipelines in the Inactive and Active States of a GPCR

Biophysical journal, 2014-07, Vol.107 (2), p.422-434

2014

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Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors

Journal of chemical theory and computation, 2014-11, Vol.10 (11), p.5149-5160

2014

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Allosteric communication regulates ligand‐specific GPCR activity

Variable G protein determinants of GPCR coupling selectivity

The role of conformational ensembles of seven transmembrane receptors in functional selectivity

How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

Conformational plasticity of the intracellular cavity of GPCR–G-protein complexes leads to G-protein promiscuity and selectivity

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Efficient and Selective Electrochemically Driven Enzyme-Catalyzed Reduction of Carbon Dioxide to Formate using Formate Dehydrogenase and an Artificial Cofactor

Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors

How Do Short Chain Nonionic Detergents Destabilize G‑Protein-Coupled Receptors?

Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

Cooperation of neurotrophin receptor TrkB and Her2 in breast cancer cells facilitates brain metastases

Dynamic Spatiotemporal Determinants Modulate GPCR:G protein Coupling Promiscuity and Biased Signaling

Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling

Structure and dynamics of a constitutively active neurotensin receptor

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors

Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

Sulfation patterns of glycosaminoglycans encode molecular recognition and activity

N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias

Catalytic site mutations confer multiple states of G protein activation

Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

Differences in Allosteric Communication Pipelines in the Inactive and Active States of a GPCR

Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors

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