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Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions

PloS one, 2013-07, Vol.8 (7), p.e67583-e67583

2013

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Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

Stem cell reports, 2016-10, Vol.7 (4), p.787-801

2016

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Recent progress on MAP kinase pathway inhibitors

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4047-4056

2015

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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (8), p.2773-2778

2008

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G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions

The Journal of biological chemistry, 2023-10, Vol.299 (10), p.105218-105218, Article 105218

2023

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G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

The Journal of biological chemistry, 2022-10, Vol.298 (10), p.102421-102421, Article 102421

2022

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Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1332-1336

2009

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Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11129-11147

2021

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Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (21), p.5738-5740

2008

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Correction to “Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma”

Journal of medicinal chemistry, 2022-01, Vol.65 (1), p.886-887

2022

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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors

ACS medicinal chemistry letters, 2013-03, Vol.4 (3), p.358-362

2013

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Biarylaniline Phenethanolamines as Potent and Selective β3 Adrenergic Receptor Agonists

Journal of medicinal chemistry, 2006-05, Vol.49 (9), p.2758-2771

2006

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A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Nature (London), , Vol.341 (6244), p.758-760

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Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.21-26

2009

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.817-820

2009

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Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I

Journal of medicinal chemistry, 1995-02, Vol.38 (3), p.395-401

1995

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Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506

Journal of the American Chemical Society, , Vol.112 (14), p.5583-5601

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Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines

Organic letters, 2000-12, Vol.2 (25), p.4099-4102

2000

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Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1004-1008

2009

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Synthesis, Topoisomerase I Inhibitory Activity, and in Vivo Evaluation of 11-Azacamptothecin Analogs

Journal of medicinal chemistry, 1995-03, Vol.38 (7), p.1106-1118

1995

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Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4670-4677

2007

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Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4436-4440

2011

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Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres

Journal of medicinal chemistry, 2002-01, Vol.45 (3), p.567-583

2002

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Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2419-2422

2006

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Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

Recent progress on MAP kinase pathway inhibitors

6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases

G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions

G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors

Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma

Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines

Correction to “Design, Synthesis, and Characterization of 4‑Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma”

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors

Biarylaniline Phenethanolamines as Potent and Selective β3 Adrenergic Receptor Agonists

A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I

Total synthesis of FK506 and an FKBP probe reagent, [C(8),C(9)-13C2]-FK506

Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines

Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Synthesis, Topoisomerase I Inhibitory Activity, and in Vivo Evaluation of 11-Azacamptothecin Analogs

Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids

Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

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