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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.360-364

2009

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Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1332-1336

2009

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2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3532-3548

2016

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Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.21-26

2009

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Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Organic letters, 2005-10, Vol.7 (21), p.4753-4756

2005

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Molecule of the Month

Current topics in medicinal chemistry, 2007-09, Vol.7 (17), p.1753-1753

Stevens, Kirk

2007

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Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3136-3140

2009

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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (21), p.5758-5762

2008

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Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1004-1008

2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.469-473

2009

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Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.373-377

2009

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2419-2422

2006

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A Convergent Approach to Coenzyme Q

Journal of the American Chemical Society, 1999-12, Vol.121 (50), p.11664-11673

1999

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Allylated aromatics via Ni-catalyzed couplings of benzylic chlorides and vinylic organometallics

Tetrahedron, 1996-05, Vol.52 (21), p.7265-7276

1996

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An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis

Tetrahedron, 1998-02, Vol.54 (7), p.1241-1253

1998

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A Novel Route to Coenzyme Q n

Journal of the American Chemical Society, 1996-06, Vol.118 (23), p.5512-5513

1996

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SYNTHESIS OF PYRAZOLO[1,5-a]PYRIDINES VIA AZIRINES: PREPARATION OF 2-(3-BROMOPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-a]PYRIDINE

Organic syntheses, 2009, Vol.86, p.18

2009

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Total Synthesis of Altohyrtin A (Spongistatin 1): Part 2

Angewandte Chemie (International ed.), 1998-02, Vol.37 (1-2), p.190-196

1998

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Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1

Angewandte Chemie (International ed.), 1998-02, Vol.37 (1-2), p.187-190

1998

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.373-377

2009

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Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (11), p.3136-3140

2009

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Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2- d]pyrimidines as EGFR and ErbB-2 inhibitors

Pyrazolo[1,5-a]pyridines as p38 Kinase Inhibitors

Molecule of the Month

Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors

Discovery and optimization of imidazo[1,2- a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors

A Convergent Approach to Coenzyme Q

Allylated aromatics via Ni-catalyzed couplings of benzylic chlorides and vinylic organometallics

An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis

A Novel Route to Coenzyme Q n

SYNTHESIS OF PYRAZOLO[1,5-a]PYRIDINES VIA AZIRINES: PREPARATION OF 2-(3-BROMOPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-a]PYRIDINE

Total Synthesis of Altohyrtin A (Spongistatin 1): Part 2

Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

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