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Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

PloS one, 2020-05, Vol.15 (5), p.e0229753-e0229753

2020

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Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds

Toxicological sciences, 2021-02, Vol.180 (1), p.103-121

2021

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A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions

Scientific reports, 2021-06, Vol.11 (1), p.12225-12225, Article 12225

2021

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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

The Journal of Toxicological Sciences, 2021, Vol.46(3), pp.99-114

2021

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Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes: Review and Case Studies

Toxicologic pathology, 2014-06, Vol.42 (4), p.725-764

2014

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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis

Regulatory toxicology and pharmacology, 2021-07, Vol.123, p.104934, Article 104934

2021

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Nonclinical Safety Biomarkers of Drug-induced Vascular Injury: Current Status and Blueprint for the Future

Toxicologic pathology, 2014-06, Vol.42 (4), p.635-657

2014

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Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform

Frontiers in molecular biosciences, 2023, Vol.10, p.1160851-1160851

2023

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Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic pathology, 2014-06, Vol.42 (4), p.765-773

2014

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Vascular Origin of Vildagliptin-induced Skin Effects in Cynomolgus Monkeys: Pathomechanistic Role of Peripheral Sympathetic System and Neuropeptide Y

Toxicologic pathology, 2014-06, Vol.42 (4), p.684-695

2014

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Evaluation of von Willebrand Factor and von Willebrand Factor Propeptide in Models of Vascular Endothelial Cell Activation, Perturbation, and/or Injury

Toxicologic pathology, 2014-06, Vol.42 (4), p.672-683

2014

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Translation Strategy for the Qualification of Drug-induced Vascular Injury Biomarkers

Toxicologic pathology, 2014-06, Vol.42 (4), p.658-671

2014

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The Role of eNOS Phosphorylation in Causing Drug-induced Vascular Injury

Toxicologic pathology, 2014-06, Vol.42 (4), p.709-724

2014

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The Relationship of Glucokinase Activator–induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies

Toxicologic pathology, 2014-06, Vol.42 (4), p.696-708

2014

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Perspectives on Drug-induced Vascular Injury

Toxicologic Pathology, 2014-06, Vol.42 (4), p.633-634

2014

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Hemodynamic Correlates of Drug-induced Vascular Injury in the Rat Using High-frequency Ultrasound Imaging

Toxicologic pathology, 2014-06, Vol.42 (4), p.784-791

2014

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Quantitative Evaluation of Drug-induced Microvascular Constriction in Mice Kidney Using a Novel Tool for 3D Geometrical Analysis of Ex vivo Organ Vasculature

Toxicologic pathology, 2014-06, Vol.42 (4), p.774-783

2014

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Sickle Cell Disease Model Mice Lacking 2,3-Dpg Show Reduced RBC Sickling and Improvements in Markers of Hemolytic Anemia

Blood, 2020-11, Vol.136 (Supplement 1), p.27-28

2020

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Effects of 2,3‐DPG knockout on SCD phenotype in Townes SCD model mice

American journal of hematology, 2023-12, Vol.98 (12), p.1838-1846

2023

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Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Advanced drug delivery reviews, 2014-05, Vol.71, p.15-33

2014

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Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies: Results from the 4th ESTP International Expert Workshop

Toxicologic pathology, 2016-08, Vol.44 (6), p.810-824

2016

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Recommendations for Clinical Pathology Data Generation, Interpretation, and Reporting in Target Animal Safety Studies for Veterinary Drug Development

International journal of toxicology, 2017-07, Vol.36 (4), p.293-302

2017

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Principles for Assessing Adversity in Toxicologic Clinical Pathology

Toxicologic pathology, 2017-02, Vol.45 (2), p.260-266

2017

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Overview

Accounting and business research, 2007-12, Vol.37 (sup1), p.75-76

Tomlinson, Lindsay

2007

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Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds

A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions

Microphysiological systems in early stage drug development: Perspectives on current applications and future impact

Formation, Clearance, Deposition, Pathogenicity, and Identification of Biopharmaceutical-related Immune Complexes: Review and Case Studies

An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis

Nonclinical Safety Biomarkers of Drug-induced Vascular Injury: Current Status and Blueprint for the Future

Fibroblast activation in response to TGFβ1 is modulated by co-culture with endothelial cells in a vascular organ-on-chip platform

Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Vascular Origin of Vildagliptin-induced Skin Effects in Cynomolgus Monkeys: Pathomechanistic Role of Peripheral Sympathetic System and Neuropeptide Y

Evaluation of von Willebrand Factor and von Willebrand Factor Propeptide in Models of Vascular Endothelial Cell Activation, Perturbation, and/or Injury

Translation Strategy for the Qualification of Drug-induced Vascular Injury Biomarkers

The Role of eNOS Phosphorylation in Causing Drug-induced Vascular Injury

The Relationship of Glucokinase Activator–induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies

Perspectives on Drug-induced Vascular Injury

Hemodynamic Correlates of Drug-induced Vascular Injury in the Rat Using High-frequency Ultrasound Imaging

Quantitative Evaluation of Drug-induced Microvascular Constriction in Mice Kidney Using a Novel Tool for 3D Geometrical Analysis of Ex vivo Organ Vasculature

Sickle Cell Disease Model Mice Lacking 2,3-Dpg Show Reduced RBC Sickling and Improvements in Markers of Hemolytic Anemia

Effects of 2,3‐DPG knockout on SCD phenotype in Townes SCD model mice

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies: Results from the 4th ESTP International Expert Workshop

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)

Recommendations for Clinical Pathology Data Generation, Interpretation, and Reporting in Target Animal Safety Studies for Veterinary Drug Development

Principles for Assessing Adversity in Toxicologic Clinical Pathology

Overview

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