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Enzyme promiscuity: a mechanistic and evolutionary perspective

Annual review of biochemistry, 2010-01, Vol.79 (1), p.471-505

2010

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Accuracy-rate tradeoffs: how do enzymes meet demands of selectivity and catalytic efficiency?

Current opinion in chemical biology, 2014-08, Vol.21, p.73-80

Tawfik, Dan S

2014

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Protein Dynamism and Evolvability

Science (American Association for the Advancement of Science), 2009-04, Vol.324 (5924), p.203-207

2009

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Stability effects of mutations and protein evolvability

Current opinion in structural biology, 2009-10, Vol.19 (5), p.596-604

2009

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Metabolite-Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

Annual review of biochemistry, 2018-06, Vol.87, p.187

2018

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Messy biology and the origins of evolutionary innovations

Nature chemical biology, 2010-10, Vol.6 (10), p.692

Tawfik, Dan S

2010

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Mutational effects and the evolution of new protein functions

Nature reviews. Genetics, 2010-08, Vol.11 (8), p.572

2010

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Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

Molecular cell, 2016-07, Vol.63 (2), p.337-346

2016

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How protein stability and new functions trade off

PLoS computational biology, 2008-02, Vol.4 (2), p.e1000002

2008

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Chaperonin overexpression promotes genetic variation and enzyme evolution

Nature, 2009-06, Vol.459 (7247), p.668-673

2009

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The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

Biochemistry (Easton), 2011-05, Vol.50 (21), p.4402-4410

2011

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How evolution shapes enzyme selectivity – lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes

The FEBS journal, 2020-04, Vol.287 (7), p.1284-1305

2020

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Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle

Science (American Association for the Advancement of Science), 2015-06, Vol.348 (6242), p.1466-1469

2015

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De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints

Cell, 2016-01, Vol.164 (3), p.476-486

2016

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On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

Molecular biology and evolution, 2016-10, Vol.33 (10), p.2633-2641

2016

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Bridging Themes: Short Protein Segments Found in Different Architectures

Molecular biology and evolution, 2021-05, Vol.38 (6), p.2191-2208

2021

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The universality of enzymatic rate–temperature dependency

Trends in biochemical sciences (Amsterdam. Regular ed.), 2014-01, Vol.39 (1), p.1-7

2014

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A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Chemical reviews, 2018-09, Vol.118 (18), p.8786-8797

2018

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Determining the interaction status and evolutionary fate of duplicated homomeric proteins

PLoS computational biology, 2020-08, Vol.16 (8), p.e1008145-e1008145

2020

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An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

PLoS biology, 2016-03, Vol.14 (3), p.e1002396-e1002396

2016

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Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

Molecular cell, 2018-10, Vol.72 (1), p.178-186.e5

2018

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Advances in laboratory evolution of enzymes

Current opinion in chemical biology, 2008-04, Vol.12 (2), p.151-158

2008

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On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate

Journal of the American Chemical Society, 2023-03, Vol.145 (15), p.8344-8354

2023

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Rescue of conformational dynamics in enzyme catalysis by directed evolution

Nature communications, 2018-04, Vol.9 (1), p.1314-11, Article 1314

2018

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Evolution of chalcone isomerase from a noncatalytic ancestor

Nature chemical biology, 2018-06, Vol.14 (6), p.548

2018

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Enzyme promiscuity: a mechanistic and evolutionary perspective

Accuracy-rate tradeoffs: how do enzymes meet demands of selectivity and catalytic efficiency?

Protein Dynamism and Evolvability

Stability effects of mutations and protein evolvability

Metabolite-Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

Messy biology and the origins of evolutionary innovations

Mutational effects and the evolution of new protein functions

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

How protein stability and new functions trade off

Chaperonin overexpression promotes genetic variation and enzyme evolution

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

How evolution shapes enzyme selectivity – lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes

Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle

De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints

On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins

Bridging Themes: Short Protein Segments Found in Different Architectures

The universality of enzymatic rate–temperature dependency

A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Determining the interaction status and evolutionary fate of duplicated homomeric proteins

An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

Automated Design of Efficient and Functionally Diverse Enzyme Repertoires

Advances in laboratory evolution of enzymes

On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate

Rescue of conformational dynamics in enzyme catalysis by directed evolution

Evolution of chalcone isomerase from a noncatalytic ancestor

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