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Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1914-1931

2014

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Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 3: Regioselective solid-phase synthesis of a 2,6,8,9-tetrasubstituted purine library

Tetrahedron letters, 2007-04, Vol.48 (16), p.2823-2827

2007

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Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

Journal of medicinal chemistry, 2013-10, Vol.56 (20), p.8163-8182

2013

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De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.3115-3119

2013

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The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells

Molecular immunology, 2009-04, Vol.46 (7), p.1458-1466

2009

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A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.417-422

2011

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Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid

Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4181-4196

1996

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A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.423-426

2011

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Total synthesis of mycophenolic acid

Canadian journal of chemistry, 1997-06, Vol.75 (6), p.641-645

1997

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Site Selectivity of the Diels−Alder Reactions of 3-[1-(tert-Butyldimethylsilyloxy)vin-1-yl]furan and 3-(Propen-2-yl)furan. Synthesis of 4-Substituted Benzofurans

Journal of organic chemistry, 1996-02, Vol.61 (4), p.1487-1492

1996

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Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

Tetrahedron letters, 2002-11, Vol.43 (45), p.8071-8073

2002

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The transformation of levopimaric acid into warburganal

Canadian journal of chemistry, 1988-07, Vol.66 (7), p.1675-1685

1988

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N-Arylpiperazinyl-N‘-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists

Journal of medicinal chemistry, 1997-08, Vol.40 (17), p.2674-2687

1997

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Total synthesis of palytoxin carboxylic acid and palytoxin amide

Journal of the American Chemical Society, 1989-09, Vol.111 (19), p.7530-7533

1989

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Total synthesis of a fully protected palytoxin carboxylic acid

Journal of the American Chemical Society, 1989-09, Vol.111 (19), p.7525-7530

1989

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Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 2: Solution phase synthesis of tetrasubstituted purines

Tetrahedron letters, 2003-11, Vol.44 (46), p.8361-8363

2003

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Synthesis of pyrimidines from 2-trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes and electron deficient acetylenes

Tetrahedron letters, 1992-06, Vol.33 (24), p.3449-3452

1992

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1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines1

Journal of organic chemistry, 1996-04, Vol.61 (7), p.2470-2483

1996

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Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids13

Bioorganic & medicinal chemistry letters, 1994-03, Vol.4 (6), p.827-830

1994

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Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids 13

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (6), p.827-830

1994

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Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids

Bioorganic & medicinal chemistry letters, 1994-03, Vol.4 (6), p.827-830

1994

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1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines 1

Journal of organic chemistry, 1996-04, Vol.61 (7), p.2470-2483

1996

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A congener study of zileuton reveals interesting effects on glucuronidation rates

Bioorganic & medicinal chemistry letters, 1994-06, Vol.4 (12), p.1437-1442

1994

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The Florisil ® catalyzed [1,3]-sigmatropic shift of allyl phenyl ethers — An entryway into novel mycophenolic acid analogues

Tetrahedron letters, 1997-07, Vol.38 (27), p.4725-4728

1997

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Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 3: Regioselective solid-phase synthesis of a 2,6,8,9-tetrasubstituted purine library

Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid

A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs

Total synthesis of mycophenolic acid

Site Selectivity of the Diels−Alder Reactions of 3-[1-(tert-Butyldimethylsilyloxy)vin-1-yl]furan and 3-(Propen-2-yl)furan. Synthesis of 4-Substituted Benzofurans

Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

The transformation of levopimaric acid into warburganal

N-Arylpiperazinyl-N‘-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists

Total synthesis of palytoxin carboxylic acid and palytoxin amide

Total synthesis of a fully protected palytoxin carboxylic acid

Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. Part 2: Solution phase synthesis of tetrasubstituted purines

Synthesis of pyrimidines from 2-trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes and electron deficient acetylenes

1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines1

Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids13

Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids 13

Improved methodology for the enantiospecific synthesis of polyunsaturated phospholipids

1,3-Diaza-1,3-butadienes. Synthesis and Conversion into Pyrimidines by [4π + 2π] Cycloaddition with Electron Deficient Acetylenes. Synthetic Utility of 2-(Trichloromethyl)pyrimidines 1

A congener study of zileuton reveals interesting effects on glucuronidation rates

The Florisil ® catalyzed [1,3]-sigmatropic shift of allyl phenyl ethers — An entryway into novel mycophenolic acid analogues

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