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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase

ChemMedChem, 2007-01, Vol.2 (1), p.58-61

2007

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Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Biochimie, 2010-11, Vol.92 (11), p.1618-1624

2010

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CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo

Molecular cancer therapeutics, 2006-05, Vol.5 (5), p.1309-1317

2006

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Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

Immunity (Cambridge, Mass.), 1999-04, Vol.10 (4), p.421-429

1999

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Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2255-2265

2011

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Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Journal of medicinal chemistry, 2003-10, Vol.46 (22), p.4702-4713

2003

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p38 mitogen activated protein kinase as a therapeutic target for Alzheimer's disease

Journal of molecular neuroscience, 2002-12, Vol.19 (3), p.295-299

Dalrymple, Stacie A

2002

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Testosterone and IL-6 Requirements for Human C-Reactive Protein Gene Expression in Transgenic Mice

The Journal of immunology (1950), 1998-06, Vol.160 (11), p.5294-5299

1998

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CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo

Molecular cancer therapeutics, 2006-07, Vol.5 (7), p.1693-1701

2006

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Targeting B cells for the treatment of rheumatoid arthritis

Arthritis research & therapy, 2003-01, Vol.5 Suppl 4 (Suppl 4), p.S7-11

2003

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A Small Molecule Ubiquitination Inhibitor Blocks NF-κB-dependent Cytokine Expression in Cells and Rats

The Journal of biological chemistry, 2002-06, Vol.277 (26), p.23573-23581

2002

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Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4884-4888

2006

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Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8 H -pyrido[2,3- d ]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2 H -pyran-4-ylamino)pyrido[2,3- d ]pyrimidin-7(8 H )-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2255-2265

2011

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The cytokine stew and innate resistance to L. monocytogenes

Immunological reviews, 1997-08, Vol.158 (1), p.107-114

1997

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Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor

The Journal of clinical investigation, 1995-06, Vol.95 (6), p.2886-2895

1995

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Identification and preclinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Biochimie, 2010-05, Vol.92 (11)

2010

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Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection

Infection and Immunity, 1996-08, Vol.64 (8), p.3231-3235

1996

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A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.417-422

2011

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Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice

Infection and Immunity, 1997-06, Vol.65 (6), p.2339-2345

1997

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A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.423-426

2011

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Subcutaneous Dosing of CRA-027483, a Small Molecule FVIIa Inhibitor, Prevents Arterial Thrombosis in a Baboon Model

Blood, 2005-11, Vol.106 (11), p.1867-1867

2005

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A Selective Small Molecule Factor VIIa Inhibitor, CRA-027483, Suppresses Acute Inflammation in Mice

Blood, 2005-11, Vol.106 (11), p.3089-3089

2005

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Models of Inflammation: Carrageenan‐Induced Paw Edema in the Rat

Current Protocols in Pharmacology, 1998-03 (1)

1998

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Models of Inflammation: Adjuvant‐Induced Arthritis in the Rat

Current Protocols in Pharmacology, 2001-08, Vol.13 (1), p.5.5.1-5.5.5

2001

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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

p38 mitogen activated protein kinase as a therapeutic target for Alzheimer's disease

Testosterone and IL-6 Requirements for Human C-Reactive Protein Gene Expression in Transgenic Mice

CRA-026440: a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo

Targeting B cells for the treatment of rheumatoid arthritis

A Small Molecule Ubiquitination Inhibitor Blocks NF-κB-dependent Cytokine Expression in Cells and Rats

Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo

The cytokine stew and innate resistance to L. monocytogenes

Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor

Identification and preclinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice

A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs

Subcutaneous Dosing of CRA-027483, a Small Molecule FVIIa Inhibitor, Prevents Arterial Thrombosis in a Baboon Model

A Selective Small Molecule Factor VIIa Inhibitor, CRA-027483, Suppresses Acute Inflammation in Mice

Models of Inflammation: Carrageenan‐Induced Paw Edema in the Rat

Models of Inflammation: Adjuvant‐Induced Arthritis in the Rat

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