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Synthesis and Biological Evaluation of Aryl-phospho-indole as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.392-395

2011

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Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4444-4449

2014

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In Vitro Inhibition of Hepadnavirus Polymerases by the Triphosphates of BMS-200475 and Lobucavir

Antimicrobial Agents and Chemotherapy, 1998-12, Vol.42 (12), p.3200-3208

1998

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Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.1891-1898

2016

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The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4323-4330

2017

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Generation of Replication-Competent Hepatitis B Virus Nucleocapsids in Insect Cells

Journal of Virology, 1998-04, Vol.72 (4), p.2765-2776

1998

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Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5427-5436

2015

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Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir

Antiviral research, 2009-02, Vol.81 (2), p.147-155

2009

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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2634-2640

2017

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Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (12), p.2699-2702

2014

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Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (18), p.4536-4541

2016

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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (18), p.3984-3991

2015

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Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor

Future medicinal chemistry, 2015-09, Vol.7 (13), p.1675

2015

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Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus

Antimicrobial Agents and Chemotherapy, 1997-07, Vol.41 (7), p.1444-1448

1997

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Interaction between hepatitis B surface proteins and monomeric human serum albumin

Hepatology (Baltimore, Md.), 1990-06, Vol.11 (6), p.1050-1056

1990

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2′-C-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

Antiviral chemistry & chemotherapy, 2007-08, Vol.18 (4), p.225-242

2007

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Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA

The EMBO journal, 1990-04, Vol.9 (4), p.1137-1145

1990

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A protease-sensitive hinge linking the two domains of the hepatitis B virus core protein is exposed on the viral capsid surface

Journal of Virology, 1994-09, Vol.68 (9), p.5548-5555

1994

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A micromolar pool of antigenically distinct precursors is required to initiate cooperative assembly of hepatitis B virus capsids in Xenopus oocytes

Journal of Virology, 1993-01, Vol.67 (1), p.249-257

1993

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In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

Journal of hepatology, 1991, Vol.13, p.S61-S65

1991

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Recombinant human hepatitis B virus reverse transcriptase is active in the absence of the nucleocapsid or the viral replication origin, DR1

Journal of Virology, 1993-08, Vol.67 (8), p.4513-4520

1993

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Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein

Journal of general virology, 1998-04, Vol.79 (4), p.767-777

1998

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Optimised Conditions for the Production of Hepatitis B Virus from Cell Culture

Intervirology, 2001, Vol.44 (6), p.370-378

2001

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Assembly and antigenicity of hepatitis B virus core particles

Intervirology, 1995, Vol.38 (1-2), p.47

1995

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Stability Governs the Apparent Expression of "Particulate" Hepatitis B e Antigen by Mutant Hepatitis B Virus Core Particles

Virology (New York, N.Y.), 1993-09, Vol.196 (1), p.70-78

1993

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Synthesis and Biological Evaluation of Aryl-phospho-indole as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease

In Vitro Inhibition of Hepadnavirus Polymerases by the Triphosphates of BMS-200475 and Lobucavir

Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

Generation of Replication-Competent Hepatitis B Virus Nucleocapsids in Insect Cells

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor

Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor

Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus

Interaction between hepatitis B surface proteins and monomeric human serum albumin

2′-C-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA

A protease-sensitive hinge linking the two domains of the hepatitis B virus core protein is exposed on the viral capsid surface

A micromolar pool of antigenically distinct precursors is required to initiate cooperative assembly of hepatitis B virus capsids in Xenopus oocytes

In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

Recombinant human hepatitis B virus reverse transcriptase is active in the absence of the nucleocapsid or the viral replication origin, DR1

Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein

Optimised Conditions for the Production of Hepatitis B Virus from Cell Culture

Assembly and antigenicity of hepatitis B virus core particles

Stability Governs the Apparent Expression of "Particulate" Hepatitis B e Antigen by Mutant Hepatitis B Virus Core Particles

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