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Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Journal of lipid research, 2015-01, Vol.56 (1), p.70-80

2015

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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

Cell metabolism, 2007-07, Vol.6 (1), p.69-78

2007

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Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status

American journal of physiology: endocrinology and metabolism, 2010-03, Vol.298 (3), p.E385-E394

2010

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Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes

Experimental biology and medicine (Maywood, N.J.), 2005-10, Vol.230 (9), p.593-605

2005

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Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus

Expert opinion on therapeutic targets, 2014-10, Vol.18 (10), p.1163-1175

2014

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Atypical protein kinase C in cardiometabolic abnormalities

Current opinion in lipidology, 2012-06, Vol.23 (3), p.175-181

2012

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Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

MedComm (2020), 2021-03, Vol.2 (1), p.3-16

2021

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The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Journal of lipid research, 2009-06, Vol.50 (6), p.1133-1145

2009

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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

American journal of physiology: endocrinology and metabolism, 2007-12, Vol.293 (6), p.E1772-E1781

2007

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Repletion of Atypical Protein Kinase C following RNA Interference-mediated Depletion Restores Insulin-stimulated Glucose Transport

The Journal of biological chemistry, 2006-06, Vol.281 (25), p.17466-17473

2006

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Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance

Cellular signalling, 2018-03, Vol.43, p.62-70

2018

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Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.25021-25030

2014

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FoxO1 Regulates Multiple Metabolic Pathways in the Liver: EFFECTS ON GLUCONEOGENIC, GLYCOLYTIC, AND LIPOGENIC GENE EXPRESSION

The Journal of biological chemistry, 2006-04, Vol.281 (15), p.10105-10117

2006

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Atypical PKC: therapeutic target for Alzheimer's?

Aging (Albany, NY.), 2018-12, Vol.11 (1), p.13-14

2018

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

Cancer cell, 2005-08, Vol.8 (2), p.155-167

2005

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Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle

The Journal of physiology, 2007-08, Vol.582 (3), p.1289-1301

2007

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BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

Metabolism, clinical and experimental, 2015-11, Vol.64 (11), p.1454-1465

2015

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Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity

Diabetes (New York, N.Y.), 2017-04, Vol.66 (4), p.920-934

2017

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Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

Neurobiology of aging, 2018-01, Vol.61, p.225-237

2018

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Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Diabetes (New York, N.Y.), 2014-08, Vol.63 (8), p.2690-2701

2014

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Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι

Diabetes (New York, N.Y.), 2002-10, Vol.51 (10), p.2936-2943

2002

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Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus

Journal of clinical medicine, 2014-07, Vol.3 (3), p.724-740

2014

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Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1

Diabetes (New York, N.Y.), 2004-06, Vol.53 (6), p.1445-1451

2004

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Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

Diabetologia, 2013-11, Vol.56 (11), p.2507-2516

2013

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Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status

Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes

Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus

Atypical protein kinase C in cardiometabolic abnormalities

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle

Repletion of Atypical Protein Kinase C following RNA Interference-mediated Depletion Restores Insulin-stimulated Glucose Transport

Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance

Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC

FoxO1 Regulates Multiple Metabolic Pathways in the Liver: EFFECTS ON GLUCONEOGENIC, GLYCOLYTIC, AND LIPOGENIC GENE EXPRESSION

Atypical PKC: therapeutic target for Alzheimer's?

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι

Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus

Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1

Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

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