UB Paderborn / Katalog / Suche / in CDI

The Role of MDM2 Amplification and Overexpression in Tumorigenesis

Cold Spring Harbor perspectives in medicine, 2016-06, Vol.6 (6), p.a026336

2016

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The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Molecular cancer therapeutics, 2015-03, Vol.14 (3), p.649-658

2015

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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.4936-4954

2012

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Diverse alterations associated with resistance to KRAS(G12C) inhibition

Nature (London), 2021-11, Vol.599 (7886), p.679-683

2021

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Identifying the determinants of response to MDM2 inhibition

Oncotarget, 2015-04, Vol.6 (10), p.7701-7712

2015

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Abstract 3761: The MDM2 inhibitor AMG 232 causes tumor regression and potentiates the anti-tumor activity of MEK inhibition and DNA-damaging cytotoxic agents in preclinical models of acute myeloid leukemia

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3761-3761

2016

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Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2472-2488

2014

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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.4053-4070

2013

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Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2014-12, Vol.57 (24), p.10499-10511

2014

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Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres

Journal of medicinal chemistry, 2014-04, Vol.57 (7), p.2963-2988

2014

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MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

Oncotarget, 2014-04, Vol.5 (8), p.2030-2043

2014

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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (9), p.2752-2755

2011

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Discovery of N‑(1-Acryloylazetidin-3-yl)-2-(1H‑indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C

ACS medicinal chemistry letters, 2019-09, Vol.10 (9), p.1302-1308

2019

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Discovery of N -(1-Acryloylazetidin-3-yl)-2-(1 H -indol-1-yl)acetamides as Covalent Inhibitors of KRAS G12C

ACS medicinal chemistry letters, 2019-09, Vol.10 (9), p.1302-1308

2019

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Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction

ACS medicinal chemistry letters, 2014-08, Vol.5 (8), p.894-899

2014

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DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones

Antimicrobial Agents and Chemotherapy, 1999-07, Vol.43 (7), p.1574-1577

1999

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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1454-1472

2014

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Abstract 1057: Combination of the KRASG12C inhibitor sotorasib with targeted agents improves anti-tumor efficacy in KRAS p.G12C cancer models

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1057-1057

2021

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Abstract 982: LKB1 loss rewires stress signaling-induced apoptotic protein dynamics and sensitizes KRAS -mutant non-small cell lung cancers to combined MAPK + MCL-1 blockade

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.982-982

2021

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Abstract 1285: In vitro characterization of sotorasib and other RAS ‘His95-groove' binders and investigation of resistance mechanisms

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1285-1285

2021

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Abstract 3871: KRAS G12C mutant allele amplification drives resistance to sotorasib in vitro

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.3871-3871

2023

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Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3090-3090

2019

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Einstellungen

The Role of MDM2 Amplification and Overexpression in Tumorigenesis

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Diverse alterations associated with resistance to KRAS(G12C) inhibition

Identifying the determinants of response to MDM2 inhibition

Abstract 3761: The MDM2 inhibitor AMG 232 causes tumor regression and potentiates the anti-tumor activity of MEK inhibition and DNA-damaging cytotoxic agents in preclinical models of acute myeloid leukemia

Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors

Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction

Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors

Discovery of N‑(1-Acryloylazetidin-3-yl)-2-(1H‑indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C

Discovery of N -(1-Acryloylazetidin-3-yl)-2-(1 H -indol-1-yl)acetamides as Covalent Inhibitors of KRAS G12C

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Abstract 1057: Combination of the KRASG12C inhibitor sotorasib with targeted agents improves anti-tumor efficacy in KRAS p.G12C cancer models

Abstract 982: LKB1 loss rewires stress signaling-induced apoptotic protein dynamics and sensitizes KRAS -mutant non-small cell lung cancers to combined MAPK + MCL-1 blockade

Abstract 1285: In vitro characterization of sotorasib and other RAS ‘His95-groove' binders and investigation of resistance mechanisms

Abstract 3871: KRAS G12C mutant allele amplification drives resistance to sotorasib in vitro

Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models

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