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Advances in therapeutic peptides targeting G protein-coupled receptors

Nature reviews. Drug discovery, 2020-06, Vol.19 (6), p.389-413

2020

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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Circulation (New York, N.Y.), 2017-03, Vol.135 (12), p.1160-1173

2017

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Evidence for biased agonists and antagonists at the endothelin receptors

Life sciences (1973), 2016-08, Vol.159, p.30-33

Maguire, Janet J.

2016

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Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

Immunity (Cambridge, Mass.), 2013-02, Vol.38 (2), p.285-295

2013

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International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function

Pharmacological reviews, 2010-09, Vol.62 (3), p.331-342

2010

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Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

European heart journal, 2020-09, Vol.41 (34), p.3239-3252

2020

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Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

Hypertension (Dallas, Tex. 1979), 2015-04, Vol.65 (4), p.834-840

2015

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The therapeutic potential of apelin in kidney disease

Nature reviews. Nephrology, 2021-12, Vol.17 (12), p.840-853

2021

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Endothelin Receptors and Their Antagonists

Seminars in nephrology, 2015-03, Vol.35 (2), p.125-136

2015

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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

Nature medicine, 2006-09, Vol.12 (9), p.1075-1080

2006

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Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

Circulation research, 2008-06, Vol.102 (12), p.1529-1538

2008

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Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites

Scientific reports, 2021-12, Vol.11 (1), p.24336-24336, Article 24336

2021

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Endothelin‐2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer

British journal of pharmacology, 2013-01, Vol.168 (2), p.283-295

2013

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Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

Frontiers in endocrinology (Lausanne), 2023-03, Vol.14, p.1139121-1139121

2023

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Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma

Frontiers in neuroscience, 2024-05, Vol.18, p.1379658-1379658

2024

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International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function

Pharmacological reviews, 2010-12, Vol.62 (4), p.565-578

2010

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Modulation of the apelin/APJ system in heart failure and atherosclerosis in man

British journal of pharmacology, 2010-08, Vol.160 (7), p.1785-1795

2010

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Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

Journal of the American Heart Association, 2016-10, Vol.5 (10), p.n/a

2016

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Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention

Journal of interventional cardiology, 2022-09, Vol.2022, p.1-7

2022

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Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

Trends in pharmacological sciences (Regular ed.), 2015-09, Vol.36 (9), p.560-567

2015

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The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Frontiers in pharmacology, 2021-01, Vol.11, p.588669-588669

2021

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Endothelin

Pharmacological reviews, 2016-04, Vol.68 (2), p.357-418

2016

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Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor

PloS one, 2011-11, Vol.6 (11), p.e27601

2011

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Is urotensin‐II the new endothelin?

British journal of pharmacology, 2002-11, Vol.137 (5), p.579-588

2002

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Discovery of a Competitive Apelin Receptor (APJ) Antagonist

ChemMedChem, 2011-06, Vol.6 (6), p.1017-1023

2011

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Advances in therapeutic peptides targeting G protein-coupled receptors

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Evidence for biased agonists and antagonists at the endothelin receptors

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function

Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

The therapeutic potential of apelin in kidney disease

Endothelin Receptors and Their Antagonists

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites

Endothelin‐2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

Expression of the apelin receptor, a novel potential therapeutic target, and its endogenous ligands in diverse stem cell populations in human glioblastoma

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function

Modulation of the apelin/APJ system in heart failure and atherosclerosis in man

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Endothelin

Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor

Is urotensin‐II the new endothelin?

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

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