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Proposal of a Safe and Effective Study Design for CYP3A‐Mediated Drug‐Drug Interactions

Journal of clinical pharmacology, 2020-10, Vol.60 (10), p.1294-1303

2020

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CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

Archives of toxicology, 2021-08, Vol.95 (8), p.2867-2870

2021

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical pharmacokinetics, 2020-06, Vol.59 (6), p.781-808

2020

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Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat

Journal of pharmacy and pharmacology, 2017-12, Vol.69 (12), p.1786-1793

2017

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CYP3A activity: towards dose adaptation to the individual

Expert opinion on drug metabolism & toxicology, 2016-05, Vol.12 (5), p.479-497

2016

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Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole

Clinical pharmacokinetics, 2016-12, Vol.55 (12), p.1535-1545

2016

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Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans

European journal of clinical pharmacology, 2022-06, Vol.78 (6), p.975-987

2022

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Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A

Palliative medicine, 2019-07, Vol.33 (7), p.850-855

2019

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Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review

Clinical pharmacokinetics, 2018-02, Vol.57 (2), p.125-149

2018

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Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine

Clinical pharmacokinetics, 2020-12, Vol.59 (12), p.1627-1639

2020

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Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

Journal of pharmacokinetics and pharmacodynamics, 2020-12, Vol.47 (6), p.527-542

2020

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A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications

Journal of pharmaceutical and biomedical analysis, 2022-02, Vol.210, p.114551-114551, Article 114551

2022

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Pharmacogenomics of the triazole antifungal agent voriconazole

Pharmacogenomics, 2011-06, Vol.12 (6), p.861

2011

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Aprepitant, granisetron, and dexamethasone for prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: results of a randomized, placebo-controlled phase III trial

Journal of clinical oncology, 2014-10, Vol.32 (30), p.3413-3420

2014

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Probes and Cocktails for Drug–Drug Interaction Evaluation: The Future Is Microdosing?

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1335-1337

Mikus, Gerd

2019

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Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery—a Prospective Clinical Study

Obesity surgery, 2020, Vol.30 (1), p.63-68

2020

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Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges

Cancers, 2023-06, Vol.15 (13), p.3293

2023

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Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

British journal of clinical pharmacology, 2009-12, Vol.68 (6), p.906-915

2009

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Midazolam microdosing applied in early clinical development for drug–drug interaction assessment

British journal of clinical pharmacology, 2021-01, Vol.87 (1), p.178-188

2021

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Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism

Pharmaceutics, 2022-02, Vol.14 (3), p.477

2022

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Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents

Clinical pharmacokinetics, 2020-05, Vol.59 (5), p.643-654

2020

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CYP2C19 Genotype Is a Major Factor Contributing to the Highly Variable Pharmacokinetics of Voriconazole

Journal of clinical pharmacology, 2009-02, Vol.49 (2), p.196-204

2009

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Quantitative low-volume assay for simultaneous determination of fentanyl, norfentanyl, and minor metabolites in human plasma and urine by liquid chromatography—tandem mass spectrometry (LC-MS/MS)

International journal of legal medicine, 2014-09, Vol.128 (5), p.771-778

2014

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Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

Expert opinion on drug metabolism & toxicology, 2013-05, Vol.9 (5), p.517-528

2013

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Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

Frontiers in pharmacology, 2023-04, Vol.14, p.1128547-1128547

2023

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Proposal of a Safe and Effective Study Design for CYP3A‐Mediated Drug‐Drug Interactions

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat

CYP3A activity: towards dose adaptation to the individual

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole

Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans

Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A

Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine

Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications

Pharmacogenomics of the triazole antifungal agent voriconazole

Aprepitant, granisetron, and dexamethasone for prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: results of a randomized, placebo-controlled phase III trial

Probes and Cocktails for Drug–Drug Interaction Evaluation: The Future Is Microdosing?

Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery—a Prospective Clinical Study

Framework for Implementing Individualised Dosing of Anti-Cancer Drugs in Routine Care: Overcoming the Logistical Challenges

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

Midazolam microdosing applied in early clinical development for drug–drug interaction assessment

Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism

Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents

CYP2C19 Genotype Is a Major Factor Contributing to the Highly Variable Pharmacokinetics of Voriconazole

Quantitative low-volume assay for simultaneous determination of fentanyl, norfentanyl, and minor metabolites in human plasma and urine by liquid chromatography—tandem mass spectrometry (LC-MS/MS)

Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

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