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Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A

Palliative medicine, 2019-07, Vol.33 (7), p.850-855

2019

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Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations

PloS one, 2013-07, Vol.8 (7), p.e67946

2013

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Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania

PloS one, 2012-07, Vol.7 (7), p.e40180

2012

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Clarithromycin substantially increases steady‐state bosentan exposure in healthy volunteers

British journal of clinical pharmacology, 2014-01, Vol.77 (1), p.141-148

2014

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Sildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure

Circulation. Heart failure, 2011-03, Vol.4 (2), p.198-206

2011

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Clinical feasibility of dried blood spots: Analytics, validation, and applications

Journal of pharmaceutical and biomedical analysis, 2016-10, Vol.130, p.231-243

2016

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Desorption/Ionization-MS Methods for Drug Quantification in Biological Matrices and Their Validation Following Regulatory Guidance

Analytical chemistry (Washington), 2021-05, Vol.93 (19), p.7152-7163

2021

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Perpetrator Characteristics of Azole Antifungal Drugs on Three Oral Factor Xa Inhibitors Administered as a Microdosed Cocktail

Clinical pharmacokinetics, 2022-01, Vol.61 (1), p.97-109

2022

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Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges

British journal of clinical pharmacology, 2021-03, Vol.87 (3), p.858-874

2021

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Rapid drug detection in whole blood droplets using a desorption electrospray ionization static profiling approach – a proof‐of‐concept

Rapid communications in mass spectrometry, 2020-03, Vol.34 (6), p.e8614-n/a

2020

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In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo–keto reductases

Archives of toxicology, 2024-03, Vol.98 (3), p.807-820

2024

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Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range

Bioanalysis, 2019-08, Vol.11 (16), p.1459-1467

2019

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Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma

Analytica chimica acta, 2020-06, Vol.1114, p.42-49

2020

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Absolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time

Journal of clinical pharmacology, 2021-04, Vol.61 (4), p.472-479

2021

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Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides – Ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS

Journal of pharmaceutical and biomedical analysis, 2021-02, Vol.194, p.113728-113728, Article 113728

2021

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Microdosing drugs: a versatile technique to detect and assess drug-drug interactions

Expert opinion on drug metabolism & toxicology, 2020-06, Vol.16 (6), p.447-448

2020

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Midazolam microdose to determine systemic and pre‐systemic metabolic CYP3A activity in humans

British journal of clinical pharmacology, 2015-02, Vol.79 (2), p.278-285

2015

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The application of P-gp inhibiting phospholipids as novel oral bioavailability enhancers — An in vitro and in vivo comparison

European journal of pharmaceutical sciences, 2017-10, Vol.108, p.13-22

2017

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Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole

Clinical pharmacokinetics, 2016-12, Vol.55 (12), p.1535-1545

2016

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Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients

British journal of pharmacology, 2021-08, Vol.178 (16), p.3294-3308

2021

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Intact plasma quantification of the large therapeutic lipopeptide bulevirtide

Analytical and bioanalytical chemistry, 2021-09, Vol.413 (22), p.5645-5654

2021

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Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses

British journal of clinical pharmacology, 2019-10, Vol.85 (10), p.2310-2320

2019

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Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC–MS/MS-Based Assay

Analytical chemistry (Washington), 2018-08, Vol.90 (15), p.9395-9402

2018

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Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics

Journal of pharmaceutical and biomedical analysis, 2020-07, Vol.186, p.113276, Article 113276

2020

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Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A

Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations

Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania

Clarithromycin substantially increases steady‐state bosentan exposure in healthy volunteers

Sildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure

Clinical feasibility of dried blood spots: Analytics, validation, and applications

Desorption/Ionization-MS Methods for Drug Quantification in Biological Matrices and Their Validation Following Regulatory Guidance

Perpetrator Characteristics of Azole Antifungal Drugs on Three Oral Factor Xa Inhibitors Administered as a Microdosed Cocktail

Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges

Rapid drug detection in whole blood droplets using a desorption electrospray ionization static profiling approach – a proof‐of‐concept

In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo–keto reductases

Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range

Post-extraction disulfide bond cleavage for MS/MS quantification of collision-induced dissociation-resistant cystine-cyclized peptides and its application to the ultra-sensitive UPLC-MS/MS bioanalysis of octreotide in plasma

Absolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time

A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy

Application of triple quadrupole tandem mass spectrometry to the bioanalysis of collision-induced dissociation-resistant cyclic peptides – Ultra-sensitive quantification of the somatostatin-analog pasireotide utilizing UHPLC-MS/MS

Microdosing drugs: a versatile technique to detect and assess drug-drug interactions

Midazolam microdose to determine systemic and pre‐systemic metabolic CYP3A activity in humans

The application of P-gp inhibiting phospholipids as novel oral bioavailability enhancers — An in vitro and in vivo comparison

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole

Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients

Intact plasma quantification of the large therapeutic lipopeptide bulevirtide

Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses

Dried-Blood-Spot Technique to Monitor Direct Oral Anticoagulants: Clinical Validation of a UPLC–MS/MS-Based Assay

Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics

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