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Targeting evolution to inhibit antibiotic resistance

The FEBS journal, 2020-10, Vol.287 (20), p.4341-4353

2020

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Targets for Combating the Evolution of Acquired Antibiotic Resistance

Biochemistry (Easton), 2015-06, Vol.54 (23), p.3573-3582

2015

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High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

Nature communications, 2020-07, Vol.11 (1), p.3455-9, Article 3455

2020

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TET enzymes, TDG and the dynamics of DNA demethylation

Nature (London), 2013-10, Vol.502 (7472), p.472-479

2013

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Low-input and single-cell methods for Infinium DNA methylation BeadChips

Nucleic acids research, 2024-02, Vol.52 (7), p.e38

2024

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The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential

ACS chemical biology, 2012-01, Vol.7 (1), p.20-30

2012

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Efficient engineering of human and mouse primary cells using peptide-assisted genome editing

Nature biotechnology, 2024-02, Vol.42 (2), p.305-315

2024

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TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites

Journal of molecular biology, 2021-04, Vol.433 (8), p.166877-166877, Article 166877

2021

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Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network

PLoS genetics, 2018-06, Vol.14 (6), p.e1007405-e1007405

2018

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Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

Molecular cell, 2021-02, Vol.81 (4), p.859-869.e8

2021

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APOBEC3 Inhibition of Mouse Mammary Tumor Virus Infection: the Role of Cytidine Deamination versus Inhibition of Reverse Transcription

Journal of Virology, 2013-05, Vol.87 (9), p.4808-4817

2013

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Tet2 Catalyzes Stepwise 5‑Methylcytosine Oxidation by an Iterative and de novo Mechanism

Journal of the American Chemical Society, 2016-01, Vol.138 (3), p.730-733

2016

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Enzymatic approaches for profiling cytosine methylation and hydroxymethylation

Molecular metabolism (Germany), 2022-03, Vol.57, p.101314-101314, Article 101314

2022

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Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies

Nature communications, 2024-01, Vol.15 (1), p.875-875, Article 875

2024

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Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo

PLoS pathogens, 2014-05, Vol.10 (5), p.e1004145-e1004145

2014

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OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

eLife, 2018-10, Vol.7

2018

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A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

The Journal of biological chemistry, 2009-08, Vol.284 (34), p.22898-22904

2009

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CRISPR tiling screen reveals cancer epigenetic 'Goldilocks' state

Trends in pharmacological sciences (Regular ed.), 2023-09, Vol.44 (9), p.555-557

2023

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Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (35), p.14225-14230

2013

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Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Frontiers in microbiology, 2018-12, Vol.9, p.2961

2018

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Biomimetic synthesis and optimization of cyclic peptide antibiotics

Nature (London), 2002-08, Vol.418 (6898), p.658-661

2002

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Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N‐Demethylation

Angewandte Chemie (International ed.), 2020-07, Vol.59 (28), p.11312-11315

International ed. in English, 2020

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Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection

Organic & biomolecular chemistry, 2017-05, Vol.15 (17), p.3603-3610

2017

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Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

mSphere, 2016-07, Vol.1 (4)

2016

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Discovery of an Unnatural DNA Modification Derived from a Natural Secondary Metabolite

Cell chemical biology, 2021-01, Vol.28 (1), p.97-104.e4

2021

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Targeting evolution to inhibit antibiotic resistance

Targets for Combating the Evolution of Acquired Antibiotic Resistance

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

TET enzymes, TDG and the dynamics of DNA demethylation

Low-input and single-cell methods for Infinium DNA methylation BeadChips

The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential

Efficient engineering of human and mouse primary cells using peptide-assisted genome editing

TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites

Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network

Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

APOBEC3 Inhibition of Mouse Mammary Tumor Virus Infection: the Role of Cytidine Deamination versus Inhibition of Reverse Transcription

Tet2 Catalyzes Stepwise 5‑Methylcytosine Oxidation by an Iterative and de novo Mechanism

Enzymatic approaches for profiling cytosine methylation and hydroxymethylation

Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies

Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

CRISPR tiling screen reveals cancer epigenetic 'Goldilocks' state

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Biomimetic synthesis and optimization of cyclic peptide antibiotics

Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N‐Demethylation

Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection

Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

Discovery of an Unnatural DNA Modification Derived from a Natural Secondary Metabolite

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