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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

The EMBO journal, 2014-07, Vol.33 (13), p.1438-1453

2014

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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

The Journal of cell biology, 2011-06, Vol.193 (6), p.1049-1064

2011

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Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

Cancer cell, 2009-12, Vol.16 (6), p.475-486

2009

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Overexpression of the E2 Ubiquitin-Conjugating Enzyme UbcH10 Causes Chromosome Missegregation and Tumor Formation

The Journal of cell biology, 2010-01, Vol.188 (1), p.83-100

2010

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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Nature cell biology, 2013-01, Vol.15 (1), p.96

2013

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Spartan deficiency causes genomic instability and progeroid phenotypes

Nature communications, 2014-12, Vol.5 (1), p.5744-5744, Article 5744

2014

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Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

The Journal of clinical investigation, 2016-02, Vol.126 (2), p.543-559

2016

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Hyperphosphorylated PTEN exerts oncogenic properties

Nature communications, 2023-05, Vol.14 (1), p.2983-2983, Article 2983

2023

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Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

PLoS genetics, 2012-12, Vol.8 (12), p.e1003138

2012

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Nature genetics, 2004-07, Vol.36 (7), p.744-749

2004

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BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.171-188

2020

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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nature communications, 2018-07, Vol.9 (1), p.2736-11, Article 2736

2018

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Cdc20 is critical for meiosis I and fertility of female mice

PLoS genetics, 2010-09, Vol.6 (9), p.e1001147-e1001147

2010

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Nature (London), 2016-02, Vol.530 (7589), p.184-189

2016

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

The Journal of cell biology, 2006-02, Vol.172 (4), p.529-540

2006

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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

The Journal of cell biology, 2010-10, Vol.191 (2), p.313-329

2010

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p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Science (American Association for the Advancement of Science), 2021-10, Vol.374 (6567), p.eabb3420-eabb3420

2021

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BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

eLife, 2016-08, Vol.5

2016

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Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

The Journal of cell biology, 2012-12, Vol.199 (6), p.931-949

2012

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Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

Nature cell biology, 2016-07, Vol.18 (7), p.814

2016

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BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

Developmental cell, 2009-01, Vol.16 (1), p.118-131

2009

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Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Gastroenterology (New York, N.Y. 1943), 2019-07, Vol.157 (1), p.210-226.e12

2019

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Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability

The Journal of cell biology, 2011-08, Vol.194 (4), p.597-612

2011

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The Rae1 - Nup98 complex prevents aneuploidy by inhibiting securin degradation

Nature, 2005-12, Vol.438 (7070), p.1036-1039

2005

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Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6307), p.1549-1552

2016

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

Overexpression of the E2 Ubiquitin-Conjugating Enzyme UbcH10 Causes Chromosome Missegregation and Tumor Formation

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Spartan deficiency causes genomic instability and progeroid phenotypes

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

Hyperphosphorylated PTEN exerts oncogenic properties

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Cdc20 is critical for meiosis I and fertility of female mice

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability

The Rae1 - Nup98 complex prevents aneuploidy by inhibiting securin degradation

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

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