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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

Cellular and molecular life sciences : CMLS, 2021-01, Vol.78 (1), p.317-335

2021

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Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Journal of medicinal chemistry, 2020-02, Vol.63 (3), p.1415-1433

2020

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Multiplex single-cell visualization of nucleic acids and protein during HIV infection

Nature communications, 2017-12, Vol.8 (1), p.1882-11, Article 1882

2017

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Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Drug metabolism and disposition, 2023-02, Vol.51 (2), p.228-236

2023

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Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

Viruses, 2023-04, Vol.15 (4), p.981

2023

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A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

Antimicrobial agents and chemotherapy, 2017-10, Vol.61 (10)

2017

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CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

Genes & diseases, 2024-07, Vol.11 (4), p.101079-101079, Article 101079

2024

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The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Acta pharmaceutica Sinica. B, 2023-11, Vol.13 (11), p.4523-4534

2023

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Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication

Viruses, 2019-07, Vol.11 (7), p.651

2019

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Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus

Viruses, 2019-11, Vol.11 (11), p.1039

2019

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Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Retrovirology, 2013-06, Vol.10 (1), p.65-65, Article 65

2013

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Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment

Cell chemical biology, 2019-03, Vol.26 (3), p.314-316

2019

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure (London), 2023-12, Vol.31 (12), p.1545-1555.e9

2023

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (10), p.e2217804120-e2217804120

2023

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CITCO Directly Binds to and Activates Human Pregnane X Receptor

Molecular pharmacology, 2020-03, Vol.97 (3), p.180-190

2020

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Regulation of PXR in drug metabolism: chemical and structural perspectives

Expert opinion on drug metabolism & toxicology, 2024, Vol.20 (1-2), p.9-15

2024

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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Nucleic acids research, 2022-04, Vol.50 (6), p.3254

2022

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Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

European journal of medicinal chemistry, 2017-12, Vol.141 (C), p.149-161

2017

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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic acids research, 2024-02, Vol.52 (4), p.1661

2024

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3‑Hydroxypyrimidine-2,4-dione-5‑N‑benzylcarboxamides Potently Inhibit HIV‑1 Integrase and RNase H

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6136-6148

2016

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6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

European journal of medicinal chemistry, 2018-08, Vol.156, p.652-665

2018

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6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

European journal of medicinal chemistry, 2018-08, Vol.156, p.680-691

2018

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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5

Journal of the American Chemical Society, 2021-11, Vol.143 (44), p.18467-18480

2021

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5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

European journal of medicinal chemistry, 2019-02, Vol.164, p.179-192

2019

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Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

Multiplex single-cell visualization of nucleic acids and protein during HIV infection

Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond

Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus

A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication

Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Discovering Anti-cancer Immune Enhancers in a Miniaturized Immune-Tumor Microenvironment

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

CITCO Directly Binds to and Activates Human Pregnane X Receptor

Regulation of PXR in drug metabolism: chemical and structural perspectives

The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

3‑Hydroxypyrimidine-2,4-dione-5‑N‑benzylcarboxamides Potently Inhibit HIV‑1 Integrase and RNase H

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

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