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Cellular and molecular mechanisms of HIV-1 integration targeting

Cellular and molecular life sciences : CMLS, 2018-07, Vol.75 (14), p.2491-2507

2018

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HIV Capsid and Integration Targeting

Viruses, 2021-01, Vol.13 (1), p.125

Engelman, Alan N

2021

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Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation

Molecular cell, 2018-01, Vol.69 (1), p.62-74.e4

2018

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A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (8), p.E1054-E1063

2016

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Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

PLoS biology, 2020-12, Vol.18 (12), p.e3001015-e3001015

2020

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Multimodal Functionalities of HIV-1 Integrase

Viruses, 2022-04, Vol.14 (5), p.926

2022

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rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

Nucleic acids research, 2021-07, Vol.49 (13), p.7330-7346

2021

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HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Nature communications, 2020-07, Vol.11 (1), p.3505-3505, Article 3505

2020

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Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Science (American Association for the Advancement of Science), 2020-10, Vol.370 (6514), p.360-364

2020

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A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site

PLoS pathogens, 2021-07, Vol.17 (7), p.e1009671

2021

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Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses, 2024-04, Vol.16 (4), p.604

2024

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Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition

The Journal of biological chemistry, 2019-10, Vol.294 (41), p.15137-15157

Engelman, Alan N.

2019

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B-to-A transition in target DNA during retroviral integration

Nucleic acids research, 2022-08, Vol.50 (15), p.8898-8918

2022

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Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

Journal of virology, 2015-10, Vol.89 (19), p.9765-9780

2015

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Retroviral DNA Integration

Chemical reviews, 2016-10, Vol.116 (20), p.12730-12757

2016

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Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Nucleic acids research, 2019-05, Vol.47 (9), p.4663-4683

2019

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Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74

Journal of virology, 2016-06, Vol.90 (12), p.5808-5823

2016

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Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

PLoS pathogens, 2022-08, Vol.18 (8), p.e1010754-e1010754

2022

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Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice

PloS one, 2015-09, Vol.10 (9), p.e0137797-e0137797

2015

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Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

Nature communications, 2022-10, Vol.13 (1), p.5879-19, Article 5879

2022

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Multiplex single-cell visualization of nucleic acids and protein during HIV infection

Nature communications, 2017-12, Vol.8 (1), p.1882-11, Article 1882

2017

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HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

Viruses, 2024-07, Vol.16 (7), p.1166

2024

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Multivalent interactions essential for lentiviral integrase function

Nature communications, 2022-05, Vol.13 (1), p.2416-2416, Article 2416

2022

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Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

mBio, 2021-03, Vol.12 (2)

2021

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Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection

Journal of virology, 2020-12, Vol.95 (2)

2020

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Cellular and molecular mechanisms of HIV-1 integration targeting

HIV Capsid and Integration Targeting

Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

Multimodal Functionalities of HIV-1 Integrase

rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site

Brief Histories of Retroviral Integration Research and Associated International Conferences

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition

B-to-A transition in target DNA during retroviral integration

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

Retroviral DNA Integration

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

Multiplex single-cell visualization of nucleic acids and protein during HIV infection

HIV-1 Intasomes Assembled with Excess Integrase C-Terminal Domain Protein Facilitate Structural Studies by Cryo-EM and Reveal the Role of the Integrase C-Terminal Tail in HIV-1 Integration

Multivalent interactions essential for lentiviral integrase function

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection

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