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Discriminating self from non-self in nucleic acid sensing

Nature reviews. Immunology, 2016-09, Vol.16 (9), p.566

2016

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Cooperative activation of human TLR9 and consequences for the clinical development of antisense and CpG oligodeoxynucleotides

Molecular therapy. Nucleic acids, 2023-12, Vol.34, p.102078, Article 102078

Hartmann, Gunther

2023

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

Nature immunology, 2009-10, Vol.10 (10), p.1065-1072

2009

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Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

Immunity (Cambridge, Mass.), 2013-09, Vol.39 (3), p.482-495

2013

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Cell, 2013-05, Vol.153 (5), p.1094-1107

2013

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Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

Nature communications, 2020-11, Vol.11 (1), p.5829-5829, Article 5829

2020

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Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help

Cell reports (Cambridge), 2021-06, Vol.35 (13), p.109320-109320, Article 109320

2021

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Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Cell, 2013-08, Vol.154 (4), p.748-762

2013

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The Chase for the RIG-I Ligand—Recent Advances

Molecular therapy, 2010-07, Vol.18 (7), p.1254-1262

2010

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Nature immunology, 2015-10, Vol.16 (10), p.1025

2015

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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

Immunity (Cambridge, Mass.), 2020-04, Vol.52 (4), p.591-605.e6

2020

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5'-Triphosphate RNA Is the Ligand for RIG-I

Science (American Association for the Advancement of Science), 2006-11, Vol.314 (5801), p.994-997

2006

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An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

Kidney international, 2016-09, Vol.90 (3), p.525-539

2016

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ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

The Journal of experimental medicine, 2018-11, Vol.215 (11), p.2868-2886

2018

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Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

Frontiers in immunology, 2023-03, Vol.14, p.1073608-1073608

2023

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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

European journal of immunology, 2010-06, Vol.40 (6), p.1545-1551

2010

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Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

Immunity (Cambridge, Mass.), 2020-07, Vol.53 (1), p.54-77

2020

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Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells

The Journal of clinical investigation, 2009-08, Vol.119 (8), p.2399-2411

2009

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Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Immunity (Cambridge, Mass.), 2009-07, Vol.31 (1), p.25-34

2009

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Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands

Scientific reports, 2021-07, Vol.11 (1), p.15231-15231, Article 15231

2021

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Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study

Clinical chemistry (Baltimore, Md.), 2017-07, Vol.63 (7), p.1288-1296

2017

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Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Circulation research, 2011-05, Vol.108 (11), p.1358-1366

2011

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Enhancement of the EGSnrc code egs_chamber for fast fluence calculations of charged particles

Zeitschrift für medizinische Physik, 2022-11, Vol.32 (4), p.417-427

2022

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Deficiency in coatomer complex I causes aberrant activation of STING signalling

Nature communications, 2022-04, Vol.13 (1), p.2321-2321, Article 2321

2022

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Quantitative protein biomarker panels: a path to improved clinical practice through proteomics

EMBO molecular medicine, 2023-04, Vol.15 (4), p.e16061-n/a

2023

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Discriminating self from non-self in nucleic acid sensing

Cooperative activation of human TLR9 and consequences for the clinical development of antisense and CpG oligodeoxynucleotides

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany

Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

The Chase for the RIG-I Ligand—Recent Advances

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

5'-Triphosphate RNA Is the Ligand for RIG-I

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands

Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study

Activation of Endothelial Toll-Like Receptor 3 Impairs Endothelial Function

Enhancement of the EGSnrc code egs_chamber for fast fluence calculations of charged particles

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Quantitative protein biomarker panels: a path to improved clinical practice through proteomics

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