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nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (2), p.582-587

2012

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A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

Science translational medicine, 2014-02, Vol.6 (225), p.225ra29

2014

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Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.5479-5484

2015

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Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

American journal of physiology. Lung cellular and molecular physiology, 2007-09, Vol.293 (3), p.L660-L667

2007

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The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

The Journal of biological chemistry, 2014-03, Vol.289 (13), p.8931-8946

2014

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Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution

The Journal of immunology (1950), 2014-02, Vol.192 (4), p.1796-1805

2014

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Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Disease models & mechanisms, 2016-06, Vol.9 (6), p.621-632

2016

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Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication

European journal of pharmacology, 2021-02, Vol.893, p.173839, Article 173839

2021

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Novel Role for the Liver X Nuclear Receptor in the Suppression of Lung Inflammatory Responses

The Journal of biological chemistry, 2007-11, Vol.282 (44), p.31882-31890

2007

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The circadian clock and asthma

Thorax, 2014-01, Vol.69 (1), p.90-92

2014

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The importance of chronobiology to drug discovery

Expert opinion on drug discovery, 2012-07, Vol.7 (7), p.535-541

2012

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Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling

The Journal of biological chemistry, 2003-11, Vol.278 (45), p.44338-44347

2003

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A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

The Journal of immunology (1950), 2010-02, Vol.184 (3), p.1516-1525

2010

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Optimized Chemical Probes for REV-ERBα

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4729-4737

2013

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Pin1 promotes GR transactivation by enhancing recruitment to target genes

Nucleic acids research, 2013-10, Vol.41 (18), p.8515

2013

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Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation

Cellular immunology, 2017-10, Vol.320, p.62-70

2017

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Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: A randomised controlled trial

Respiratory medicine, 2010-05, Vol.104 (5), p.668-674

2010

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Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism

The Journal of immunology (1950), 2002-06, Vol.168 (12), p.6232-6243

2002

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A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

Journal of cell science, 2013-07, Vol.126 (Pt 14), p.3159-3169

2013

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Nuclear receptors: doubling up in the lung

Current opinion in pharmacology, 2008-06, Vol.8 (3), p.275-279

Farrow, Stuart N

2008

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Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

FEBS letters, 2000-11, Vol.485 (2), p.135-141

2000

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Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504)

The Journal of pharmacology and experimental therapeutics, 2009-02, Vol.328 (2), p.458

2009

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The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages

International immunopharmacology, 2010, Vol.10 (1), p.57-64

2010

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A death-domain-containing receptor that mediates apoptosis

Nature (London), 1996-11, Vol.384 (6607), p.372-375

1996

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DR3 Regulates Negative Selection during Thymocyte Development

Molecular and Cellular Biology, 2001-05, Vol.21 (10), p.3451-3461

2001

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nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication

Novel Role for the Liver X Nuclear Receptor in the Suppression of Lung Inflammatory Responses

The circadian clock and asthma

The importance of chronobiology to drug discovery

Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling

A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

Optimized Chemical Probes for REV-ERBα

Pin1 promotes GR transactivation by enhancing recruitment to target genes

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation

Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: A randomised controlled trial

Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

Nuclear receptors: doubling up in the lung

Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)

The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages

A death-domain-containing receptor that mediates apoptosis

DR3 Regulates Negative Selection during Thymocyte Development

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