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Progress towards a public chemogenomic set for protein kinases and a call for contributions

PloS one, 2017-08, Vol.12 (8), p.e0181585-e0181585

2017

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Quantifying CDK inhibitor selectivity in live cells

Nature communications, 2020-06, Vol.11 (1), p.2743-2743, Article 2743

2020

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Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

Current topics in medicinal chemistry, 2014-02, Vol.14 (3), p.340

2014

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (4), p.1006-1011

2006

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The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

Endocrine reviews, 2002-10, Vol.23 (5), p.687-702

2002

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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Journal of medicinal chemistry, 2019-03, Vol.62 (5), p.2830-2836

2019

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.2950

2023

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4016

2019

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Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

ChemMedChem, 2018-01, Vol.13 (1), p.48-66

2018

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The PPARs: From Orphan Receptors to Drug Discovery

Journal of medicinal chemistry, 2000-02, Vol.43 (4), p.527-550

2000

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Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity

Pharmaceuticals (Basel, Switzerland), 2024-02, Vol.17 (3), p.306

2024

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Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds

Communications chemistry, 2022-10, Vol.5 (1), p.129-129, Article 129

2022

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In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

Molecules (Basel, Switzerland), 2020-01, Vol.25 (2), p.325

2020

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Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

The Journal of biological chemistry, 2002-01, Vol.277 (4), p.2908-2915

2002

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Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

The Journal of biological chemistry, 2010-01, Vol.285 (5), p.3035-3043

2010

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Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (11), p.7604-7609

2002

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Structural Basis for an Unexpected Mode of SERM-Mediated ER Antagonism

Molecular cell, 2005-05, Vol.18 (4), p.413-424

2005

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The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

Science (American Association for the Advancement of Science), 2001-06, Vol.292 (5525), p.2329-2333

2001

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Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Cell, 2002-07, Vol.110 (1), p.93-105

2002

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Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes

The Journal of biological chemistry, 2003-05, Vol.278 (19), p.17277-17283

2003

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The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction

The Journal of biological chemistry, 2004-05, Vol.279 (19), p.19832-19838

2004

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Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Molecular cell, 2003-04, Vol.11 (4), p.1093-1100

2003

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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5418), p.1365-1368

1999

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Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

Journal of lipid research, 2002-03, Vol.43 (3), p.359-364

2002

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A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor[boxs]

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.31283-31293

2005

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Progress towards a public chemogenomic set for protein kinases and a call for contributions

Quantifying CDK inhibitor selectivity in live cells

Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

The PPARs: From Orphan Receptors to Drug Discovery

Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity

Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

Synthetic LXR Ligand Inhibits the Development of Atherosclerosis in Mice

Structural Basis for an Unexpected Mode of SERM-Mediated ER Antagonism

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes

The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction

Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor[boxs]

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