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Dragging Ras Back in the Ring

Cancer cell, 2014-03, Vol.25 (3), p.272-281

2014

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Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Clinical cancer research, 2015-04, Vol.21 (8), p.1819-1827

2015

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Nature (London), 2013-11, Vol.503 (7477), p.548-551

2013

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KRAS as a Therapeutic Target

Clinical cancer research, 2015-04, Vol.21 (8), p.1797-1801

McCormick, Frank

2015

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (7), p.2551-2560

2019

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Cell, 2018-01, Vol.172 (3), p.578-589.e17

2018

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Cancer: The Ras renaissance

Nature (London), 2015-04, Vol.520 (7547), p.278-280

Ledford, Heidi

2015

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Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Genes & development, 2013-05, Vol.27 (10), p.1101-1114

2013

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Molecular cancer research, 2015-09, Vol.13 (9), p.1325-1335

2015

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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature communications, 2021-02, Vol.12 (1), p.1176-1176, Article 1176

2021

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KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Clinical cancer research, 2019-01, Vol.25 (2), p.796-807

2019

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Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Nature (London), 2013-05, Vol.497 (7451), p.638-642

2013

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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Nature (London), 2023-07, Vol.619 (7968), p.160-166

2023

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Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Nature (London), 2020-01, Vol.577 (7790), p.421-425

2020

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The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Journal of hematology and oncology, 2020-08, Vol.13 (1), p.113-19, Article 113

2020

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Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.771-785

2016

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Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

Cell, 2017-01, Vol.168 (1-2), p.239-251.e16

2017

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Cytoplasmic chromatin triggers inflammation in senescence and cancer

Nature (London), 2017-10, Vol.550 (7676), p.402-406

2017

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Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects

Clinical cancer research, 2015-04, Vol.21 (8), p.1810-1818

2015

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Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma

Oncogene, 2016-06, Vol.35 (24), p.3209-3216

2016

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Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function

American journal of physiology. Heart and circulatory physiology, 2017-11, Vol.313 (5), p.H890-H895

2017

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Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (34), p.E5024-E5033

2016

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KRAS mutation: from undruggable to druggable in cancer

Signal transduction and targeted therapy, 2021-11, Vol.6 (1), p.386-20, Article 386

2021

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Targeting KRAS -Mutant Non-Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on KRAS G12C Mutations

Journal of clinical oncology, 2020-12, Vol.38 (35), p.4208-4218

2020

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Nature (London), 2013-04, Vol.496 (7443), p.101-105

2013

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Dragging Ras Back in the Ring

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

KRAS as a Therapeutic Target

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Cancer: The Ras renaissance

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects

Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma

Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function

Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence

KRAS mutation: from undruggable to druggable in cancer

Targeting KRAS -Mutant Non-Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on KRAS G12C Mutations

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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