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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Nature communications, 2022-10, Vol.13 (1), p.6363-6363, Article 6363

2022

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Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis

PLoS genetics, 2012-05, Vol.8 (5), p.e1002650

2012

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KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature communications, 2021-02, Vol.12 (1), p.1176-1176, Article 1176

2021

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KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Cancer cell, 2012-01, Vol.21 (1), p.105-120

2012

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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (14), p.6471-6476

2010

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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (19), p.9433-9442

2019

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Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Clinical cancer research, 2015-04, Vol.21 (8), p.1819-1827

2015

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Cell, 2018-01, Vol.172 (3), p.578-589.e17

2018

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Molecular cancer research, 2015-09, Vol.13 (9), p.1325-1335

2015

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Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Nature (London), 2020-01, Vol.577 (7790), p.421-425

2020

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Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum

Toxicology and applied pharmacology, 2016-10, Vol.309, p.24-36

2016

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (7), p.2551-2560

2019

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KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Clinical cancer research, 2019-01, Vol.25 (2), p.796-807

2019

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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Nature (London), 2023-07, Vol.619 (7968), p.160-166

2023

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Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

Cell, 2017-01, Vol.168 (1-2), p.239-251.e16

2017

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The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

Clinical cancer research, 2012-04, Vol.18 (8), p.2316-2325

2012

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KRAS as a Therapeutic Target

Clinical cancer research, 2015-04, Vol.21 (8), p.1797-1801

McCormick, Frank

2015

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A structural model of a Ras-Raf signalosome

Nature structural & molecular biology, 2021-10, Vol.28 (10), p.847-857

2021

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The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects

The Journal of biological chemistry, 2017-08, Vol.292 (31), p.12981-12993

2017

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Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

Molecular cell, 2016-03, Vol.61 (5), p.705-719

2016

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Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.771-785

2016

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Dragging Ras Back in the Ring

Cancer cell, 2014-03, Vol.25 (3), p.272-281

2014

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Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Nature communications, 2016-05, Vol.7 (1), p.11363-13, Article 11363

2016

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KRAS mutation: from undruggable to druggable in cancer

Signal transduction and targeted therapy, 2021-11, Vol.6 (1), p.386-20, Article 386

2021

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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

KRAS as a Therapeutic Target

A structural model of a Ras-Raf signalosome

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Dragging Ras Back in the Ring

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

KRAS mutation: from undruggable to druggable in cancer

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