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Rh(III)-Catalyzed C–H Activation and Double Directing Group Strategy for the Regioselective Synthesis of Naphthyridinones

Journal of the American Chemical Society, 2013-10, Vol.135 (39), p.14492-14495

2013

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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.11401-11420

2024

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Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.15050-15071

2020

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Synthesis of Indolo[1,2‑a][1,8]naphthyridines by Rhodium(III)-Catalyzed Dehydrogenative Coupling via Rollover Cyclometalation

Organic letters, 2015-06, Vol.17 (12), p.3130-3133

2015

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Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1473-1480

2011

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Discovery of 2,6-Naphthyridine Analogues as Selective FGFR4 Inhibitors for Hepatocellular Carcinoma

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8445-8459

2024

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Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.635-654

2011

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In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

Antimicrobial Agents and Chemotherapy, 2011-02, Vol.55 (2), p.813-821

2011

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Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase

European journal of medicinal chemistry, 2016-11, Vol.124, p.740-749

2016

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Rhodium(III)-Catalyzed Oxidative Olefination of Pyridines and Quinolines: Multigram-Scale Synthesis of Naphthyridinones

Organic letters, 2013-07, Vol.15 (13), p.3460-3463

2013

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Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole

Angewandte Chemie International Edition, 2012-05, Vol.51 (21), p.5217-5221

International ed. in English, 2012

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Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2010-10, Vol.53 (19), p.7146-7155

2010

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Novel Double [3 + 2 + 1] Heteroannulation for Forming Unprecedented Dipyrazolo-Fused 2,6-Naphthyridines

Organic letters, 2013-05, Vol.15 (9), p.2258-2261

2013

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Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8858-8875

2017

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Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (−)-Calycanthine

Journal of organic chemistry, 2015-10, Vol.80 (20), p.10309-10316

2015

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Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity

European journal of medicinal chemistry, 2016-06, Vol.115, p.179-190

2016

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On Water: Silver-Catalyzed Domino Approach for the Synthesis of Benzoxazine/Oxazine-Fused Isoquinolines and Naphthyridines from o‑Alkynyl Aldehydes

Journal of organic chemistry, 2013-07, Vol.78 (13), p.6657-6669

2013

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Concise Total Synthesis of (−)-Calycanthine, (+)-Chimonanthine, and (+)-Folicanthine

Angewandte Chemie International Edition, 2007-01, Vol.46 (20), p.3725-3728

2007

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Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold

European journal of medicinal chemistry, 2020-01, Vol.185, p.111803-111803, Article 111803

2020

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Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

Bioorganic & medicinal chemistry letters, 2021-10, Vol.49, p.128314-128314, Article 128314

2021

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Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

ChemMedChem, 2012-08, Vol.7 (8), p.1385-1403

2012

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Fused 1,5-Naphthyridines: Synthetic Tools and Applications

Molecules (Basel, Switzerland), 2020-07, Vol.25 (15), p.3508

2020

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Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives

European journal of medicinal chemistry, 2019-11, Vol.182, p.111627-111627, Article 111627

2019

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Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (−)- and (+)-Folicanthine

Chemistry : a European journal, 2015-11, Vol.21 (48), p.17479-17484

2015

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Antioxidant and Antimicrobial Potential of 1,8‐Naphthyridine Based Scaffolds: Design, Synthesis and in Silico Simulation Studies within Topoisomerase II

Chemistry & biodiversity, 2024-06, Vol.21 (6), p.e202301746-n/a

2024

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Rh(III)-Catalyzed C–H Activation and Double Directing Group Strategy for the Regioselective Synthesis of Naphthyridinones

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches

Synthesis of Indolo[1,2‑a][1,8]naphthyridines by Rhodium(III)-Catalyzed Dehydrogenative Coupling via Rollover Cyclometalation

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Discovery of 2,6-Naphthyridine Analogues as Selective FGFR4 Inhibitors for Hepatocellular Carcinoma

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase

Rhodium(III)-Catalyzed Oxidative Olefination of Pyridines and Quinolines: Multigram-Scale Synthesis of Naphthyridinones

Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Novel Double [3 + 2 + 1] Heteroannulation for Forming Unprecedented Dipyrazolo-Fused 2,6-Naphthyridines

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (−)-Calycanthine

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity

On Water: Silver-Catalyzed Domino Approach for the Synthesis of Benzoxazine/Oxazine-Fused Isoquinolines and Naphthyridines from o‑Alkynyl Aldehydes

Concise Total Synthesis of (−)-Calycanthine, (+)-Chimonanthine, and (+)-Folicanthine

Synthesis and biological evaluation of new MET inhibitors with 1,6-naphthyridinone scaffold

Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold

Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases

Fused 1,5-Naphthyridines: Synthetic Tools and Applications

Targeting multiple G-quadruplex–forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives

Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (−)- and (+)-Folicanthine

Antioxidant and Antimicrobial Potential of 1,8‐Naphthyridine Based Scaffolds: Design, Synthesis and in Silico Simulation Studies within Topoisomerase II

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