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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Oncogene, 2007-05, Vol.26 (22), p.3291-3310

2007

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Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

Molecular cell, 2013-01, Vol.49 (2), p.249-261

2013

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A Brief Ischemic Postconditioning Protects Against Amyloid-β Peptide Neurotoxicity by Downregulating MLK3-MKK3/6-P38MAPK Signal in Rat Hippocampus

Journal of Alzheimer's disease, 2019-01, Vol.71 (2), p.671-684

2019

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Targeting the RAF–MEK–ERK pathway in cancer therapy

Cancer letters, 2009-10, Vol.283 (2), p.125-134

2009

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Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts

Experimental cell research, 2012-10, Vol.318 (16), p.2105-2115

2012

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TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19900-19909

2015

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Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

Journal of hepatology, 2012-01, Vol.56 (1), p.192-198

2012

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Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF‑α Production

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6690-6709

2022

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Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice

British journal of pharmacology, 2015-12, Vol.172 (23), p.5559-5572

2015

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The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells

The Journal of biological chemistry, 2020-06, Vol.295 (25), p.8470-8479

2020

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Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells

Nature immunology, 2011-06, Vol.12 (6), p.544-550

2011

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Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5

Cancer research (Chicago, Ill.), 2006-12, Vol.66 (24), p.11851-11858

2006

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The Evolution of Melanoma Resistance Reveals Therapeutic Opportunities

Cancer research (Chicago, Ill.), 2013-10, Vol.73 (20), p.6106-6110

2013

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

Cancer research (Chicago, Ill.), 2004-10, Vol.64 (19), p.7099-7109

2004

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A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways

Cancer letters, 2019-07, Vol.455, p.60-72

2019

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Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial

JNCI : Journal of the National Cancer Institute, 2017-05, Vol.109 (5)

2017

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ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion

International journal of oncology, 2012-05, Vol.40 (5), p.1714

2012

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Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma

Science translational medicine, 2015-03, Vol.7 (279), p.279ra41

2015

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Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

British journal of pharmacology, 2014-01, Vol.171 (1), p.224-236

2014

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Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor

PloS one, 2014-06, Vol.9 (6), p.e100880

2014

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Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Cell death & disease, 2020-07, Vol.11 (7), p.574, Article 574

2020

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PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling

Cancer research (Chicago, Ill.), 2010-09, Vol.70 (17), p.6804-6814

2010

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

A Brief Ischemic Postconditioning Protects Against Amyloid-β Peptide Neurotoxicity by Downregulating MLK3-MKK3/6-P38MAPK Signal in Rat Hippocampus

Targeting the RAF–MEK–ERK pathway in cancer therapy

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts

TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage

Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF‑α Production

Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells

Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5

The Evolution of Melanoma Resistance Reveals Therapeutic Opportunities

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways

Target and Agent Prioritization for the Children's Oncology Group-National Cancer Institute Pediatric MATCH Trial

ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell invasion

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

PIK3CA Mutation Uncouples Tumor Growth and Cyclin D1 Regulation from MEK/ERK and Mutant KRAS Signaling

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