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Abstract 1955 Expression of hERG, a voltage-gated K+ channel alpha-subunit, is affected by combinatorial phosphorylation in the HEK-293 model system

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.107013, Article 107013

2024

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On the relationship between hERG inhibition and the magnitude of QTc prolongation: An in vitro to clinical translational analysis

Toxicology and applied pharmacology, 2024-11, Vol.492, p.117135, Article 117135

2024

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Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG

Cell, 2017-04, Vol.169 (3), p.422-430.e10

2017

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hERG toxicity assessment: Useful guidelines for drug design

European journal of medicinal chemistry, 2020-06, Vol.195, p.112290, Article 112290

2020

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hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107293-107293, Article 107293

2023

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High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Heart rhythm, 2020-12, Vol.17 (12), p.2180-2189

2020

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Rescue of expression and function of long QT syndrome-causing mutant hERG channels by enhancing channel stability in the plasma membrane

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107526, Article 107526

2024

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Abstract 1672 Validating the use of acceptor photobleach FRET in quantifying protein-protein interactions between K+ channel alpha-subunits hERG and KvLQT1

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106950, Article 106950

2024

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Abstract 1960 The N-terminal Per-Arnt-Sim (PAS) domain of hERG channels allosterically regulates channel closure and couples the voltage sensor to the pore gate

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.107015, Article 107015

2024

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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

British journal of pharmacology, 2024-04, Vol.181 (7), p.987-1004

2024

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Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

European journal of medicinal chemistry, 2021-02, Vol.212, p.113033, Article 113033

2021

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Validation and Clinical Utility of the hERG IC50:Cmax Ratio to Determine the Risk of Drug‐Induced Torsades de Pointes: A Meta‐Analysis

Pharmacotherapy, 2018-03, Vol.38 (3), p.341-348

2018

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Multiple hERG channel blocking pathways: implications for macromolecules

Trends in pharmacological sciences (Regular ed.), 2024-08, Vol.45 (8), p.671-677

Zünkler, Bernd J.

2024

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1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum

ACS medicinal chemistry letters, 2022-06, Vol.13 (6), p.955-963

2022

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Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

Insect biochemistry and molecular biology, 2020-03, Vol.118, p.103310-103310, Article 103310

2020

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Hydroxychloroquine induces long QT syndrome by blocking hERG channel

Frigid Zone Medicine (Warsaw. Online), 2023-05, Vol.3 (2), p.105-113

2023

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Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/− long QT syndrome variant

Cardiovascular research, 2023-11, Vol.119 (15), p.2522-2535

2023

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The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel KV11.1 associated with long QT syndrome

The Journal of biological chemistry, 2024-07, Vol.300 (7), p.107465, Article 107465

2024

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hERG subunit composition determines differential drug sensitivity

British journal of pharmacology, 2011-09, Vol.164 (2b), p.419-432

2011

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Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with alpha 1-adrenoceptor affinities

Bioorganic & medicinal chemistry, 2012-04, Vol.20 (7), p.2290-2303

2012

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Toxicology profile of a novel GLP-1 receptor biased agonist-SAL0112 in nonhuman primates

Toxicology and applied pharmacology, 2024-11, Vol.492, p.117125, Article 117125

2024

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Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

Structure (London), 2021-03, Vol.29 (3), p.203-212.e4

2021

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Antipsychotics and risk of QT prolongation: a pharmacovigilance study

Psychopharmacology, 2023-01, Vol.240 (1), p.199-202

2023

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In silico prediction of hERG blockers using machine learning and deep learning approaches

Journal of applied toxicology, 2023-10, Vol.43 (10), p.1462-1475

2023

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Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native I Kr Currents and on Cardiac Action Potential

Toxicological sciences, 2019-04, Vol.168 (2), p.365-380

2019

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Abstract 1955 Expression of hERG, a voltage-gated K+ channel alpha-subunit, is affected by combinatorial phosphorylation in the HEK-293 model system

On the relationship between hERG inhibition and the magnitude of QTc prolongation: An in vitro to clinical translational analysis

Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG

hERG toxicity assessment: Useful guidelines for drug design

hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Rescue of expression and function of long QT syndrome-causing mutant hERG channels by enhancing channel stability in the plasma membrane

Abstract 1672 Validating the use of acceptor photobleach FRET in quantifying protein-protein interactions between K+ channel alpha-subunits hERG and KvLQT1

Abstract 1960 The N-terminal Per-Arnt-Sim (PAS) domain of hERG channels allosterically regulates channel closure and couples the voltage sensor to the pore gate

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

Validation and Clinical Utility of the hERG IC50:Cmax Ratio to Determine the Risk of Drug‐Induced Torsades de Pointes: A Meta‐Analysis

Multiple hERG channel blocking pathways: implications for macromolecules

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum

Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies

Hydroxychloroquine induces long QT syndrome by blocking hERG channel

Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/− long QT syndrome variant

The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel KV11.1 associated with long QT syndrome

hERG subunit composition determines differential drug sensitivity

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with alpha 1-adrenoceptor affinities

Toxicology profile of a novel GLP-1 receptor biased agonist-SAL0112 in nonhuman primates

Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole

Antipsychotics and risk of QT prolongation: a pharmacovigilance study

In silico prediction of hERG blockers using machine learning and deep learning approaches

Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native I Kr Currents and on Cardiac Action Potential

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