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Glutathionylation primes soluble glyceraldehyde-3-phosphate dehydrogenase for late collapse into insoluble aggregates

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.26057-26065

2019

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4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Nature communications, 2019-11, Vol.10 (1), p.5091-11, Article 5091

2019

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SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Molecular cell, 2015-07, Vol.59 (2), p.321-332

2015

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Beyond glycolysis: GAPDHs are multi-functional enzymes involved in regulation of ROS, autophagy, and plant immune responses

PLoS genetics, 2015-04, Vol.11 (4), p.e1005199-e1005199

2015

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Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (42), p.20984-20990

2019

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Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

The Journal of biological chemistry, 2018-09, Vol.293 (37), p.14557-14568

2018

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Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages

PloS one, 2012-01, Vol.7 (1), p.e29963-e29963

2012

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Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications

Physiologia plantarum, 2008-06, Vol.133 (2), p.211-228

2008

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Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism

The EMBO journal, 2021-08, Vol.40 (15), p.e106800-n/a

2021

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A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma

Cancer research (Chicago, Ill.), 2022-04, Vol.82 (7), p.1251-1266

2022

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Structural analysis of glyceraldehyde-3-phosphate dehydrogenase functional diversity

The international journal of biochemistry & cell biology, 2014-12, Vol.57, p.20-26

Sirover, Michael A.

2014

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Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

The Journal of biological chemistry, 2020-01, Vol.295 (1), p.111-124

2020

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Stain-Free technology as a normalization tool in Western blot analysis

Analytical biochemistry, 2013-02, Vol.433 (2), p.105-111

2013

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Glutathionylation of cytosolic glyceraldehyde-3-phosphate dehydrogenase from the model plant Arabidopsis thaliana is reversed by both glutaredoxins and thioredoxins in vitro

Biochemical journal, 2012-08, Vol.445 (3), p.337-347

2012

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On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: Biochemical mechanisms and regulatory control

Biochimica et biophysica acta, 2011-08, Vol.1810 (8), p.741-751

Sirover, Michael A.

2011

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A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

Nature chemical biology, 2015-02, Vol.11 (2), p.156-163

2015

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Binding of alpha-synuclein to partially oxidized glyceraldehyde-3-phosphate dehydrogenase induces subsequent inactivation of the enzyme

Archives of biochemistry and biophysics, 2018-03, Vol.642, p.10-22

2018

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Oxidation of the active site cysteine residue of glyceraldehyde-3-phosphate dehydrogenase to the hyper-oxidized sulfonic acid form is favored under crowded conditions

Free radical biology & medicine, 2024-02, Vol.212, p.1-9

2024

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Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

Cell metabolism, 2019-06, Vol.29 (6), p.1410-1421.e4

2019

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GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Nature communications, 2021-11, Vol.12 (1), p.6666-6666, Article 6666

2021

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Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Science (American Association for the Advancement of Science), 2018-04, Vol.360 (6387), p.449-453

2018

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The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection

Gene therapy, 2024-09, Vol.31 (9-10), p.467-476

2024

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Calvin–Benson cycle regulation is getting complex

Trends in plant science, 2021-09, Vol.26 (9), p.898-912

2021

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Molecular identification of GAPDHs in cassava highlights the antagonism of MeGAPCs and MeATG8s in plant disease resistance against cassava bacterial blight

Plant molecular biology, 2018-06, Vol.97 (3), p.201-214

2018

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Reprogramming the translatome during daily light transitions as affected by cytosolic glyceraldehyde-3-phosphate dehydrogenases GAPC1/C2

Journal of experimental botany, 2024-04, Vol.75 (8), p.2494-2509

2024

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Glutathionylation primes soluble glyceraldehyde-3-phosphate dehydrogenase for late collapse into insoluble aggregates

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Beyond glycolysis: GAPDHs are multi-functional enzymes involved in regulation of ROS, autophagy, and plant immune responses

Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages

Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications

Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism

A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma

Structural analysis of glyceraldehyde-3-phosphate dehydrogenase functional diversity

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

Stain-Free technology as a normalization tool in Western blot analysis

Glutathionylation of cytosolic glyceraldehyde-3-phosphate dehydrogenase from the model plant Arabidopsis thaliana is reversed by both glutaredoxins and thioredoxins in vitro

On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: Biochemical mechanisms and regulatory control

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

Binding of alpha-synuclein to partially oxidized glyceraldehyde-3-phosphate dehydrogenase induces subsequent inactivation of the enzyme

Oxidation of the active site cysteine residue of glyceraldehyde-3-phosphate dehydrogenase to the hyper-oxidized sulfonic acid form is favored under crowded conditions

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection

Calvin–Benson cycle regulation is getting complex

Molecular identification of GAPDHs in cassava highlights the antagonism of MeGAPCs and MeATG8s in plant disease resistance against cassava bacterial blight

Reprogramming the translatome during daily light transitions as affected by cytosolic glyceraldehyde-3-phosphate dehydrogenases GAPC1/C2

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