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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Nature (London), 2017-12, Vol.552 (7684), p.194-199

2017

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Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Biomaterials, 2022-02, Vol.281, p.121335-121335, Article 121335

2022

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Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy

Angewandte Chemie International Edition, 2023-03, Vol.62 (12), p.e202213922-n/a

International ed. in English, 2023

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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Nature immunology, 2020-07, Vol.21 (7), p.736

2020

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Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder

Drugs (New York, N.Y.), 2022-02, Vol.82 (3), p.251-274

2022

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Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

Antiviral research, 2018-02, Vol.150, p.155-163

2018

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Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

Nature communications, 2022-11, Vol.13 (1), p.6862-6862, Article 6862

2022

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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Nature cell biology, 2022-01, Vol.24 (1), p.62

2022

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Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes

International journal of pharmaceutics, 2024-05, Vol.657, p.124187-124187, Article 124187

2024

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New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

Nature medicine, 2014-04, Vol.20 (4), p.425-429

2014

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Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

Oncogene, 2019-10, Vol.38 (40), p.6711-6722

2019

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Disulfiram-based disulfides as narrow-spectrum antibacterial agents

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1298-1302

2018

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Disulfiram-loaded metal organic framework for precision cancer treatment via ultrasensitive tumor microenvironment-responsive copper chelation and radical generation

Journal of colloid and interface science, 2022-06, Vol.615, p.517-526

2022

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Nanomedicine Enables Drug-Potency Activation with Tumor Sensitivity and Hyperthermia Synergy in the Second Near-Infrared Biowindow

ACS nano, 2021-04, Vol.15 (4), p.6457-6470

2021

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DDTC-Cu(I) based metal-organic framework (MOF) for targeted melanoma therapy by inducing SLC7A11/GPX4-mediated ferroptosis

Colloids and surfaces, B, Biointerfaces, 2023-05, Vol.225, p.113253-113253, Article 113253

2023

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Reactive oxygen species-activated self-amplifying prodrug nanoagent for tumor-specific Cu-chelate chemotherapy and cascaded photodynamic therapy

Biomaterials, 2022-05, Vol.284, p.121513-121513, Article 121513

2022

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Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases

Acta pharmacologica Sinica, 2021-11, Vol.42 (11), p.1913-1920

2021

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Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4835-4844

2015

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Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite

Antimicrobial agents and chemotherapy, 2022-11, Vol.66 (11), p.e0083222

2022

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Overcoming the compensatory increase in NRF2 induced by NPL4 inhibition enhances disulfiram/copper-induced oxidative stress and ferroptosis in renal cell carcinoma

European journal of pharmacology, 2023-12, Vol.960, p.176110-176110, Article 176110

2023

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Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II)

Biochemical pharmacology, 2020-12, Vol.182, p.114267, Article 114267

2020

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Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Current medicinal chemistry, 2018-02, Vol.25 (4), p.506

2018

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Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway

Biological and Pharmaceutical Bulletin, 2021/10/01, Vol.44(10), pp.1557-1564

2021

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Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations

The Journal of clinical investigation, 2015-05, Vol.125 (5), p.1901-1912

2015

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Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer

Biomacromolecules, 2024-05, Vol.25 (5), p.2770-2779

2024

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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

Disulfiram-based disulfides as narrow-spectrum antibacterial agents

Disulfiram-loaded metal organic framework for precision cancer treatment via ultrasensitive tumor microenvironment-responsive copper chelation and radical generation

Nanomedicine Enables Drug-Potency Activation with Tumor Sensitivity and Hyperthermia Synergy in the Second Near-Infrared Biowindow

DDTC-Cu(I) based metal-organic framework (MOF) for targeted melanoma therapy by inducing SLC7A11/GPX4-mediated ferroptosis

Reactive oxygen species-activated self-amplifying prodrug nanoagent for tumor-specific Cu-chelate chemotherapy and cascaded photodynamic therapy

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite

Overcoming the compensatory increase in NRF2 induced by NPL4 inhibition enhances disulfiram/copper-induced oxidative stress and ferroptosis in renal cell carcinoma

Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II)

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma via ROS/Mitochondria Pathway

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations

Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer

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