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Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain

PloS one, 2013-08, Vol.8 (8), p.e70690

2013

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Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis

Circulation (New York, N.Y.), 2021-02, Vol.143 (6), p.606-608

2021

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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (35), p.E8143-E8152

2018

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Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy

Journal of the American College of Cardiology, 2021-12, Vol.78 (25), p.2518-2532

2021

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The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

Pharmacology & therapeutics (Oxford), 2018-01, Vol.181, p.1-12

Fessler, Michael B

2018

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Inflammation, Immunity, and Hypertensive End-Organ Damage

Circulation research, 2015-03, Vol.116 (6), p.1022-1033

2015

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SarcTrack

Circulation research, 2019-04, Vol.124 (8), p.1172

2019

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Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

Nature neuroscience, 2019-11, Vol.22 (11), p.1782-1792

2019

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Akt Pathway Inhibitors

Current topics in medicinal chemistry, 2020-01, Vol.20 (10), p.883-900

2020

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Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

Neuron (Cambridge, Mass.), 2018-05, Vol.98 (4), p.726-735.e4

2018

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Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10263-10286

2020

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Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.E7486-E7494

2018

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Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

Cell, 2011-09, Vol.147 (1), p.223-234

2011

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Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation

Thorax, 2020-11, Vol.75 (11), p.918-927

2020

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AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Cancer cell, 2011-01, Vol.19 (1), p.58-71

2011

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Dose-Blinded Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Outcomes Through 32 Weeks

Circulation (New York, N.Y.), 2023-03, Vol.147 (11), p.850-863

2023

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CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease

European journal of clinical investigation, 2018-11, Vol.48 (S2), p.e12949-n/a

2018

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Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4849-4858

2016

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Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

Nature (London), 2013-10, Vol.502 (7471), p.372-376

2013

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Safinamide: A Review in Parkinson’s Disease

CNS drugs, 2017-02, Vol.31 (2), p.169-176

2017

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SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

Autophagy, 2020-06, Vol.16 (6), p.1092-1110

2020

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Evolution of a 4‑Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.2854-2876

2020

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CXCR4 chemokine antagonist scores a first FDA approval for WHIM syndrome

Nature reviews. Drug discovery, 2024-06, Vol.23 (6), p.411-411

Mullard, Asher

2024

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Exploring New and Old Therapies for Obstructive Hypertrophic Cardiomyopathy: Mavacamten in Perspective

Circulation (New York, N.Y.), 2021-03, Vol.143 (12), p.1181-1183

2021

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A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

PloS one, 2016-12, Vol.11 (12), p.e0168407

2016

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Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain

Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

Inflammation, Immunity, and Hypertensive End-Organ Damage

SarcTrack

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

Akt Pathway Inhibitors

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Dose-Blinded Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Outcomes Through 32 Weeks

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

Safinamide: A Review in Parkinson’s Disease

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

Evolution of a 4‑Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders

CXCR4 chemokine antagonist scores a first FDA approval for WHIM syndrome

Exploring New and Old Therapies for Obstructive Hypertrophic Cardiomyopathy: Mavacamten in Perspective

A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

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