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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

Journal of the American Chemical Society, 2019-02, Vol.141 (8), p.3507-3514

2019

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A Natural-Product Switch for a Dynamic Protein Interface

Angewandte Chemie (International ed.), 2014-06, Vol.53 (25), p.6443-6448

International ed. in English, 2014

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Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome–Inhibitor Interaction Landscapes

Journal of chemical information and modeling, 2019-03, Vol.59 (3), p.1221-1229

2019

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A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Angewandte Chemie (International ed.), 2004-06, Vol.43 (24), p.3118-3133

2004

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Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria

Nature chemistry, 2024-09, Vol.16 (9), p.1462-1472

2024

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From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile

Thrombosis and haemostasis, 2009-11, Vol.102 (5), p.804-810

2009

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Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.9096-9104

2014

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Structure–Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors

Journal of medicinal chemistry, 2024-07, Vol.67 (14), p.12331-12348

2024

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Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N -Acylphosphatidylethanolamine Phospholipase D

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.481-515

2021

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Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin

ChemMedChem, 2008-08, Vol.3 (8), p.1189-1193

2008

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Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors

Bioorganic & medicinal chemistry, 2019-03, Vol.27 (5), p.692-699

2019

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Asymmetric Synthesis of Lysine Analogues with Reduced Basicity, and their Incorporation into Proteasome Inhibitors

European journal of organic chemistry, 2017-10, Vol.2017 (39), p.5921-5934

2017

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Surface Plasmon Resonance Evaluation of Various Aminoglycoside-RNA Hairpin Interactions Reveals Low Degree of Selectivity

Chembiochem : a European journal of chemical biology, 2004-07, Vol.5 (7), p.937-942

2004

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Synthetic heparin derivatives as new anticoagulant drugs

Drug discovery today, 2005-06, Vol.10 (11), p.769-779

2005

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Targeting RNA: new opportunities to address drugless targets

Drug Discovery Today, 2003-04, Vol.8 (7), p.297-306

2003

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Stereoselective Transformations on d-Glucose-Derived Eight-Membered Ring Carbocycles

Organic letters, 2001-03, Vol.3 (5), p.731-733

2001

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Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4419-4432

2002

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The State of the Art of Chemical Biology

Chembiochem : a European journal of chemical biology, 2009-01, Vol.10 (1), p.16-29

2009

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The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Angewandte Chemie (International ed.), 1993-12, Vol.32 (12), p.1671-1690

1993

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Fondaparinux, a Synthetic Pentasaccharide: The First in a New Class of Antithrombotic Agents — The Selective Factor Xa Inhibitors

Cardiovascular drug reviews, 2002-03, Vol.20 (1), p.37-52

2002

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A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Nature communications, 2023-12, Vol.14 (1), p.8039-8039, Article 8039

2023

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Constructing a molecular model of the interaction between antithrombin III and a potent heparin analog

Journal of the American Chemical Society, 1991-03, Vol.113 (7), p.2743-2747

1991

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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

A Natural-Product Switch for a Dynamic Protein Interface

Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome–Inhibitor Interaction Landscapes

A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria

From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile

Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors

Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses

Structure–Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N -Acylphosphatidylethanolamine Phospholipase D

Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin

Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors

Asymmetric Synthesis of Lysine Analogues with Reduced Basicity, and their Incorporation into Proteasome Inhibitors

Surface Plasmon Resonance Evaluation of Various Aminoglycoside-RNA Hairpin Interactions Reveals Low Degree of Selectivity

Synthetic heparin derivatives as new anticoagulant drugs

Targeting RNA: new opportunities to address drugless targets

Stereoselective Transformations on d-Glucose-Derived Eight-Membered Ring Carbocycles

Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics

Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index

The State of the Art of Chemical Biology

The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Fondaparinux, a Synthetic Pentasaccharide: The First in a New Class of Antithrombotic Agents — The Selective Factor Xa Inhibitors

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

Constructing a molecular model of the interaction between antithrombin III and a potent heparin analog

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