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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Journal of medicinal chemistry, 2012-09, Vol.55 (18), p.8110-8127

2012

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Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

Cancer biology & therapy, 2011-11, Vol.12 (9), p.788-796

2011

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Discovery of pyrrolopyrimidine inhibitors of Akt

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (19), p.5607-5612

2010

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7037-7041

2010

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Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520

Molecular cancer therapeutics, 2010-07, Vol.9 (7), p.2046-2056

2010

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Abstract A94: STAT3 antisense treatment decreases M2 macrophage infiltration and enhances the activity of checkpoint inhibitors in preclinical tumor models

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A94-A94

2015

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Abstract 2939: Chk1 inhibition and Wee1 inhibition combine synergistically to inhibit cellular proliferation

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2939-2939

2011

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Pyrazolopyridine Inhibitors of B-Raf V600E . Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

ACS medicinal chemistry letters, 2011-05, Vol.2 (5), p.342-347

2011

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Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content

Molecular pharmacology, 1990-10, Vol.38 (4), p.471-480

1990

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Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II

Cancer research (Chicago, Ill.), 1990-05, Vol.50 (10), p.2901-2908

1990

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Microautoradiographic Quantitation of Vascular Endothelial Growth Factor mRNA Levels in Human Prostate Specimens Containing Normal and Neoplastic Epithelium

Experimental and molecular pathology, 1998-01, Vol.65 (1), p.37-52

1998

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Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content

Oncology research, 1992, Vol.4 (11-12), p.481

1992

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Decreased vascular endothelial growth factor expression associated with tumor regression induced by (E)-2'-deoxy-2'-(fluoromethylene)cytidine (MDL 101,731)

Oncology research, 1997, Vol.9 (10), p.543

1997

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Quantitation of Vascular Endothelial Growth Factor mRNA Levels in Human Breast Tumors and Metastatic Lymph Nodes

Experimental and molecular pathology, 1997-02, Vol.64 (1), p.41-51

1997

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Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin

FEBS letters, 1990-12, Vol.276 (1), p.17-20

1990

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STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer

JNCI : Journal of the National Cancer Institute, 2019-12, Vol.111 (12), p.1339-1349

2019

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Beet the Best?: Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease With Intermittent Claudication

Circulation research, 2018-08, Vol.123 (6), p.654-659

2018

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Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

Leukemia, 2009-10, Vol.23 (10), p.1755-1762

2009

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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

The Journal of clinical investigation, 2018-12, Vol.128 (12), p.5479-5488

2018

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Impact of a Novel Training Approach on Hemodynamic and Vascular Profiles in Older Adults

Journal of aging and physical activity, 2022-04, Vol.30 (2), p.196

2022

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Beet the Best?

Circulation research, 2018-08, Vol.123 (6), p.654-659

2018

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Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

Journal for immunotherapy of cancer, 2020-07, Vol.8 (2)

2020

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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520

Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Abstract A94: STAT3 antisense treatment decreases M2 macrophage infiltration and enhances the activity of checkpoint inhibitors in preclinical tumor models

Abstract 2939: Chk1 inhibition and Wee1 inhibition combine synergistically to inhibit cellular proliferation

Pyrazolopyridine Inhibitors of B-Raf V600E . Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content

Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II

Microautoradiographic Quantitation of Vascular Endothelial Growth Factor mRNA Levels in Human Prostate Specimens Containing Normal and Neoplastic Epithelium

Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content

Decreased vascular endothelial growth factor expression associated with tumor regression induced by (E)-2'-deoxy-2'-(fluoromethylene)cytidine (MDL 101,731)

Quantitation of Vascular Endothelial Growth Factor mRNA Levels in Human Breast Tumors and Metastatic Lymph Nodes

Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin

STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer

Beet the Best?: Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease With Intermittent Claudication

Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Impact of a Novel Training Approach on Hemodynamic and Vascular Profiles in Older Adults

Beet the Best?

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

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