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The molecular pathogenesis of the myelodysplastic syndromes

European journal of haematology, 2015-07, Vol.95 (1), p.3-15

2015

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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Nature cell biology, 2019-05, Vol.21 (5), p.640

2019

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SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

Blood, 2020-07, Vol.136 (2), p.157-170

2020

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Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications

Advances in biological regulation, 2017-01, Vol.63, p.59-70

2017

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IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Blood, 2015-05, Vol.125 (20), p.3144-3152

2015

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Application of CRISPR/Cas9 genome editing to the study and treatment of disease

Archives of toxicology, 2015-07, Vol.89 (7), p.1023-1034

2015

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Nature genetics, 2010-08, Vol.42 (8), p.722-726

2010

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Gene expression and risk of leukemic transformation in myelodysplasia

Blood, 2017-12, Vol.130 (24), p.2642-2653

2017

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Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Nature communications, 2018-10, Vol.9 (1), p.4004-18, Article 4004

2018

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Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Molecular cell, 2014-05, Vol.54 (3), p.445-459

2014

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ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

Blood cancer journal (New York), 2021-09, Vol.11 (9), p.157-157, Article 157

2021

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Advances in the 5q− syndrome

Blood, 2010-12, Vol.116 (26), p.5803-5811

2010

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Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Cancer research (Chicago, Ill.), 2017-09, Vol.77 (18), p.4846-4857

2017

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Recent Advances in the 5q- Syndrome

Mediterranean journal of hematology and infectious diseases, 2015-05, Vol.7 (1), p.e2015037-e2015037

2015

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Presentation Name: Insights from the MDS transcriptome

Leukemia research, 2021-09, Vol.108, p.106682, Article 106682.2

Boultwood, Jacqueline

2021

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The molecular pathogenesis of the myelodysplastic syndromes

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Application of CRISPR/Cas9 genome editing to the study and treatment of disease

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

Gene expression and risk of leukemic transformation in myelodysplasia

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

Advances in the 5q− syndrome

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Recent Advances in the 5q- Syndrome

Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes

Recurrent ETNK1 mutations in atypical chronic myeloid leukemia

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Presentation Name: Insights from the MDS transcriptome

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